41 datasets found
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Federal
Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program
U.S. Environmental Protection Agency —
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the... -
Federal
The Tox21 10K Compound Library: Part 1 - Collaborative chemistry advancing toxicology
U.S. Environmental Protection Agency —
Table S1: Tox21 IDs mapped to NCGC IDs, PubChem IDs, and DSSTox IDs, and indicating NCATS, NTP and EPA partner library associations (date stamped February 24, 2020).... -
Federal
Screening silver nanoparticles for potential neurotoxicity using cortical neurons grown on microelectrode arrays
U.S. Environmental Protection Agency —
the zip files contain outputs from the R-analysis for the nanosilver experiments. This dataset is associated with the following publication: Strickland, J., W. LeFew,... -
Federal
Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data
U.S. Environmental Protection Agency —
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were... -
Federal
Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)
U.S. Environmental Protection Agency —
Figure S1: BMC curves. Table S1: Fish assessments. Table S2: Data to make visualization of toxicity (Figure 3). Table S3: Data to make BMC curves. This dataset is... -
Federal
Blog | Introducing Chemical Effects in Biological Systems (CEBS): a Database of Toxicological Data
U.S. Department of Health & Human Services —
This blog post was posted by Ellie Sheridan on July 29, 2016. -
Federal
Functional Use Database (FUse)
U.S. Environmental Protection Agency —
There are five different files for this dataset: 1. A dataset listing the reported functional uses of chemicals (FUse) 2. All 729 ToxPrint descriptors obtained from... -
Federal
Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries
U.S. Environmental Protection Agency —
These are the raw data files for TOXSCI manuscript 19-0578 entitled, “Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase... -
Federal
High-throughput Toxicogenomic Screening of Chemicals in the Environment Using Metabolically Competent, Human-derived Hepatic Cell Cultures
U.S. Environmental Protection Agency —
Gene expression data from the Fluidigm qRT-PCR arrays was analyzed in R (v3.6.1; R Foundation for Statistical Computing, 2019). Prior to processing through the tcpl... -
Federal
High-Throughput Transcriptomics Platform for Screening Environmental Chemicals
U.S. Environmental Protection Agency —
We screened 44 chemicals in MCF7 cells in concentration response and generated HTTr data using the TempO-Seq hWTv1 assay. First, we provide an outline of the quality... -
Federal
Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment
U.S. Environmental Protection Agency —
Table S1. All chemicals and AC50 from invitrodb v3 for human FACTORIAL-TRANS assay endpoints. Table S2. Agreement with OECD reference AR agonists. Table S3. Agreement... -
Federal
Judson_Kleinstreuer_Development and Validation of a Computational Model for Androgen Receptor Activity.
U.S. Environmental Protection Agency —
Data on 1855 chemicals were generated during ToxCast Phases I and II and Tox21 screening using 11 AR-related in vitro assays to build a computational network model... -
Federal
MMartin_DFiler_tcpl: the ToxCast pipeline for high-throughput screening data
U.S. Environmental Protection Agency —
The tcpl package provides a set of tools for processing and modeling high-throughput and high-content chemical screening data. This dataset is associated with the... -
Federal
The Alginate Immobilization of Metabolic Enzymes (AIME) Platform Retrofits an Estrogen Receptor Transactivation Assay with Metabolic Competence
U.S. Environmental Protection Agency —
The objective of this study was to develop an approach to retrofit existing HTS assays with hepatic metabolism. The Alginate Immobilization of Metabolic Enzymes... -
Federal
Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library
U.S. Environmental Protection Agency —
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist... -
Federal
Development, validation and integration of in silico models to identify androgen active chemicals
U.S. Environmental Protection Agency —
A diverse data set of 1667 chemicals with AR experimental activity were provided by the U.S. EPA from the oxicity Forecaster (ToxCast) program which generates data... -
Federal
Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment
U.S. Environmental Protection Agency —
Supplemental data for "Schaupp CM, Maloney EM, Mattingly K, Olker JH, Villeneuve DL. Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a... -
Federal
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
U.S. Environmental Protection Agency —
Supplementary data for "Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung, Sigmund J. Degitz, Assessing utility of thyroid in vitro... -
Federal
Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals
U.S. Environmental Protection Agency —
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern....
41 datasets found