30 datasets found
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Federal
Quantitative Structure-Use Relationship (QSUR) Model Descriptors 12 recent views
U.S. Environmental Protection Agency —
This data set contains ToxPrint finger prints for all chemicals in FUse that had QSAR-ready SMILES strings as well as select physicochemical properties from the... -
Federal
The Tox21 10K Compound Library: Part 1 - Collaborative chemistry advancing toxicology 11 recent views
U.S. Environmental Protection Agency —
Table S1: Tox21 IDs mapped to NCGC IDs, PubChem IDs, and DSSTox IDs, and indicating NCATS, NTP and EPA partner library associations (date stamped February 24, 2020).... -
Federal
Functional Use Database (FUse) 11 recent views
U.S. Environmental Protection Agency —
There are five different files for this dataset: 1. A dataset listing the reported functional uses of chemicals (FUse) 2. All 729 ToxPrint descriptors obtained from... -
Federal
Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data
U.S. Environmental Protection Agency —
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were... -
Federal
Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program
U.S. Environmental Protection Agency —
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the... -
Federal
High-throughput Toxicogenomic Screening of Chemicals in the Environment Using Metabolically Competent, Human-derived Hepatic Cell Cultures
U.S. Environmental Protection Agency —
Gene expression data from the Fluidigm qRT-PCR arrays was analyzed in R (v3.6.1; R Foundation for Statistical Computing, 2019). Prior to processing through the tcpl... -
Federal
Dataset for ORD-033294: Mining a human transcriptome database for chemical modulators of NRF2
U.S. Environmental Protection Agency —
Gene Expression Omnibus and ArrayExpress archived study numbers of microarray data used in the study. This dataset is associated with the following publication:... -
Federal
KPF_Examining the Utility of In Vitro Bioactivity as a Protective Point of Departure: A Case Study_APCRA
U.S. Environmental Protection Agency —
The files and .R scripts here are provided to aid in understanding and reproduction of the analyses in the submitted paper, "Examining the Utility of In Vitro... -
Federal
Screening silver nanoparticles for potential neurotoxicity using cortical neurons grown on microelectrode arrays
U.S. Environmental Protection Agency —
the zip files contain outputs from the R-analysis for the nanosilver experiments. This dataset is associated with the following publication: Strickland, J., W. LeFew,... -
Federal
Development, validation and integration of in silico models to identify androgen active chemicals
U.S. Environmental Protection Agency —
A diverse data set of 1667 chemicals with AR experimental activity were provided by the U.S. EPA from the oxicity Forecaster (ToxCast) program which generates data... -
Federal
Quantitative Structure-Use Relationship Model Predictions to evaluate Tox21 Chemicals as Functional Substitutes and Candidate Alternatives
U.S. Environmental Protection Agency —
This dataset provides a prediction for all Tox21 chemicals with available QSUR descriptors across all 41 valid QSUR models developed with FUse. This dataset is... -
Federal
Simmons_DeGroot_Metabolism_mRNA_transfection_ApplInVitroTox_Data
U.S. Environmental Protection Agency —
The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS)... -
Federal
Judson_Kleinstreuer_Development and Validation of a Computational Model for Androgen Receptor Activity.
U.S. Environmental Protection Agency —
Data on 1855 chemicals were generated during ToxCast Phases I and II and Tox21 screening using 11 AR-related in vitro assays to build a computational network model... -
Federal
Targeted Per- and Polyfluoroalkyl Substances (PFAS) Assessments for High Throughput Screening: Analytical and Testing Considerations to Inform a PFAS Stock Quality Evaluation Framework
U.S. Environmental Protection Agency —
Data for "Smeltz MG, Clifton MS, Henderson WM, McMillan L, Wetmore BA. Targeted Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening:... -
Federal
Judson_RefChem_InVitro_Assays
U.S. Environmental Protection Agency —
This supplemental material describes two sets of methods; first, it briefly describes the process used to create the EPA’s LitDB database, and second, it describes... -
Federal
Watt_HTS_Uncertainty_Quantification_2017_data
U.S. Environmental Protection Agency —
In this work, we introduce a new method for uncertainty quantification in ToxCast data. We explore how unavoidable uncertainties in the data result in uncertainties... -
Federal
Dataset for ORD-033364: Identification of Novel Activators of the Metal Responsive Transcription Factor (MTF-1) Using a Gene Expression Biomarker in a Microarray Compendium
U.S. Environmental Protection Agency —
The microarray experiments examined in the study. This dataset is associated with the following publication: Jackson, A., J. Liu, B. Vallanat, C. Jones, M. Nelms, G.... -
Federal
Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries
U.S. Environmental Protection Agency —
These are the raw data files for TOXSCI manuscript 19-0578 entitled, “Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase... -
Federal
A cross-platform approach to characterize and screen potential neurovascular unit toxicants
U.S. Environmental Protection Agency —
Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and...
30 datasets found
