Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were downloaded and converted from g/ml into micromolar concentrations prior to calculation of mMds and data simulation (Supplemental Data 1).
This dataset is associated with the following publication:
Haggard, D., W. Setzer, R. Judson, and K. Friedman. Development of a prioritization method for chemical-mediated effects on steroidogenesis using an integrated statistical analysis of high-throughput H295R data. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 109: 104510, (2019).
Resources
2 resources available
-
https://cran.r-project.org/web/packages/tcpl/index.html
FILE -
Supplemental_Haggard_et_al_mahalanobis_prioritization.zip
APPLICATION/X-ZIP-COMPRESSED
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Keith Houck",
"hasEmail": "mailto:houck.keith@epa.gov"
}
|
| description | HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were downloaded and converted from g/ml into micromolar concentrations prior to calculation of mMds and data simulation (Supplemental Data 1). This dataset is associated with the following publication: Haggard, D., W. Setzer, R. Judson, and K. Friedman. Development of a prioritization method for chemical-mediated effects on steroidogenesis using an integrated statistical analysis of high-throughput H295R data. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 109: 104510, (2019). |
| distribution |
[
{
"title": "https://cran.r-project.org/web/packages/tcpl/index.html",
"accessURL": "https://cran.r-project.org/web/packages/tcpl/index.html"
},
{
"title": "Supplemental_Haggard_et_al_mahalanobis_prioritization.zip",
"mediaType": "application/x-zip-compressed",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503880/Supplemental_Haggard_et_al_mahalanobis_prioritization.zip"
}
]
|
| identifier | https://doi.org/10.23719/1503880 |
| keyword |
[
"High throughput screening",
"Steriodogenesis",
"ToxCast",
"chemical prioritization",
"endocrine disruption",
"high throughput toxicology"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-05-21 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1016/j.yrtph.2019.104510"
]
|
| rights |
null
|
| title | Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data |
