Skip to main content
U.S. flag

An official website of the United States government

Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: April 21, 2026 at 08:04 PM | Dataset Last Updated: September 21, 2020
Table S1. All chemicals and AC50 from invitrodb v3 for human FACTORIAL-TRANS assay endpoints. Table S2. Agreement with OECD reference AR agonists. Table S3. Agreement with OECD reference ER agonists. Table S4. Agreement with OECD reference ER antagonists. Table S5. Summary results of 191 test chemicals AC50 agreements Table S6. Curve fitting parameters for all endpoints. Word File: Supplementary data. This dataset is associated with the following publication: Houck, K., A. Simha, A. Bone, J. Doering, S. Vliet, C. LaLone, A. Medvedev, and S. Makarov. Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 72: 105016, (2021).

Resources

7 resources available

  • Supplemental Data, S1.docx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT
    Download

  • TableS1.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • TableS2.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • TableS3.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • TableS4.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • TableS5.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • TableS6.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

Find Related Datasets

Search by Tags

Click any tag below to search for similar datasets

Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Keith Houck",
  "hasEmail": "mailto:houck.keith@epa.gov"
}
description Table S1. All chemicals and AC50 from invitrodb v3 for human FACTORIAL-TRANS assay endpoints. Table S2. Agreement with OECD reference AR agonists. Table S3. Agreement with OECD reference ER agonists. Table S4. Agreement with OECD reference ER antagonists. Table S5. Summary results of 191 test chemicals AC50 agreements Table S6. Curve fitting parameters for all endpoints. Word File: Supplementary data. This dataset is associated with the following publication: Houck, K., A. Simha, A. Bone, J. Doering, S. Vliet, C. LaLone, A. Medvedev, and S. Makarov. Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 72: 105016, (2021).
distribution 
[
  {
    "title": "Supplemental Data, S1.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518765/Supplemental%20Data%2C%20S1.docx"
  },
  {
    "title": "TableS1.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518765/TableS1.xlsx"
  },
  {
    "title": "TableS2.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518765/TableS2.xlsx"
  },
  {
    "title": "TableS3.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518765/TableS3.xlsx"
  },
  {
    "title": "TableS4.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518765/TableS4.xlsx"
  },
  {
    "title": "TableS5.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518765/TableS5.xlsx"
  },
  {
    "title": "TableS6.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1518765/TableS6.xlsx"
  }
]
identifier https://doi.org/10.23719/1518765
keyword 
[
  "Endocrine Disruptors",
  "High throughput screening",
  "ToxCast",
  "ecotoxicoloty",
  "high throughput toxicology",
  "multiplexed assay",
  "nuclear receptor",
  "reporter gene",
  "zebrafish"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2020-09-21
programCode 
[
  "020:095"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
[
  "https://doi.org/10.1016/j.tiv.2020.105016"
]
rights 
null
title Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment

data.gov

An official website of the GSA's Technology Transformation Services

Looking for U.S. government information and services?
Visit USA.gov