78 datasets found
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Federal
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
U.S. Environmental Protection Agency —
Data from a large-scale modeling project called CERAPP (Collaborative Estrogen Receptor Activity Prediction Project) demonstrating using predictive computational... -
Federal
Screening the ToxCast Chemical Libraries for Binding to Transthyretin
U.S. Environmental Protection Agency —
Supporting information for "Screening the ToxCast Chemical Libraries for Binding to Transthyretin". This dataset is associated with the following publication:... -
Federal
“The influence of control group reproduction on the statistical power of the Environmental Protection Agency’s Medaka Extended One Generation Reproduction Test (MEOGRT) data for simulations” Dataset
U.S. Environmental Protection Agency —
Excel spreadsheet that contains the raw fecundity data used to conduct power simulations specific to the MEOGRT reproductive assessment. This dataset is associated... -
Federal
Extracting and benchmarking emerging adverse outcome pathway knowledge
U.S. Environmental Protection Agency —
A collection of R scripts useful for extracting and analyzing adverse outcome pathway network data from the adverse outcome pathway wiki (aopwiki.org). This dataset... -
Federal
Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase (CYP19) Activity Among 18 Freshwater Fishes
U.S. Environmental Protection Agency —
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic... -
Federal
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and Gene Expression in the Ovary of Female Fathead Minnows (Pimephales promelas)
U.S. Environmental Protection Agency —
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect... -
Federal
Conversion of environmental estrone to estradiol by male fathead minnows
U.S. Environmental Protection Agency —
This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations... -
Federal
Data File 1: Metabolism of cyclic phenones in rainbow trout in vitro assays
U.S. Environmental Protection Agency —
Files contain summary reports of chemical and Mass Spectrometry raw and analyzed data used as basis for plot generation and text discussions in the Cyclic phenone... -
Federal
Medaka Extended One-Generation Reproduction Test (MEOGRT) of 2-Ethylhexyl 4-Hydroxybenzoate
U.S. Environmental Protection Agency —
Evaluation of multigenerational effects of 2-ethylhexyl 4-hydroxybenzoate in Japanese medaka Abstract The Japanese medaka (Oryzias latipes) extended one-generation... -
Federal
Larval fathead minnow swim bladder inflation following exposure to 2-mercaptobenzothiazole
U.S. Environmental Protection Agency —
In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was... -
Federal
A case study on the use of exposure-activity ratios (EARs) to prioritize sites, chemicals, and bioactivities of concern in Great Lakes waters
U.S. Environmental Protection Agency —
As a case study, chemical occurrence data from a 2012 study in the Great Lakes Basin along with the ToxCast™ effects database were used to calculate exposure-activity... -
Federal
A study of temporal effects of the model anti-androgen flutamide on components of the hypothalamic-pituitary-gonadal axis in adult fathead minnows
U.S. Environmental Protection Agency —
The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal axis of fathead minnow treated with the model androgen receptor (AR)... -
Federal
Identifying chemicals and mixtures of potential biological concern detected in passive samplers from Great Lakes tributaries using high-throughput data and biological pathways
U.S. Environmental Protection Agency —
Water-borne contaminants were monitored in 69 tributaries of the Laurentian Great Lakes in 2010 and 2014 using semipermeable membrane devices (SPMDs), and polar... -
Federal
Dataset and code for cross species applicability of an AOP network for thyroid hormone system disruption
U.S. Environmental Protection Agency —
The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database... -
Federal
Male Fathead Minnow Transcriptomes and Associated Chemical Analytes in Milwaukee Estuary System
U.S. Environmental Protection Agency —
This dataset presents the full hepatic transcriptomes of fathead minnows (Pimephales promelas) caged for four days at multiple sites within the Milwaukee Estuary area... -
Federal
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium
U.S. Environmental Protection Agency —
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium. This dataset is associated with the... -
Federal
Estimating Intermittent Individual Spawning Behavior via Disaggregating Group Data
U.S. Environmental Protection Agency —
In order to understand fish biology and reproduction it is important to know the fecundity patterns of individual fish, as frequently established by recording the... -
Federal
Effects of metformin and its metabolite guanylurea on fathead minnow (Pimephales promelas) reproduction
U.S. Environmental Protection Agency —
Data associated with exposures of fathead minnows to varying concentrations of metformin and/or guanylurea. Includes three individual studies: ex vivo steroidogenesis... -
Federal
Phenone rtER binding Vtg_Tapper_A-jm6n_data set 20171002
U.S. Environmental Protection Agency —
Phenones and hydroxy benzophenones are widely used as UV radiation filters, and in the manufacturing of insecticides and pharmaceuticals. Understanding the ability of... -
Federal
Potential toxicity of complex mixtures in surface waters from a nationwide survey of United States streams: Identifying in vitro bioactivities and causative chemicals
U.S. Environmental Protection Agency —
In vitro biological activity data from a extracts of a nationwide survey of US streams. This dataset is associated with the following publication: Blackwell, B., G....
78 datasets found