75 datasets found
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Federal
Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA)
U.S. Environmental Protection Agency —
Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using... -
Federal
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
U.S. Environmental Protection Agency —
Data from a large-scale modeling project called CERAPP (Collaborative Estrogen Receptor Activity Prediction Project) demonstrating using predictive computational... -
Federal
Medaka Extended One-Generation Reproduction Test (MEOGRT) of 2-Ethylhexyl 4-Hydroxybenzoate
U.S. Environmental Protection Agency —
Evaluation of multigenerational effects of 2-ethylhexyl 4-hydroxybenzoate in Japanese medaka Abstract The Japanese medaka (Oryzias latipes) extended one-generation... -
Federal
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and Gene Expression in the Ovary of Female Fathead Minnows (Pimephales promelas)
U.S. Environmental Protection Agency —
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect... -
Federal
Data for Summary of the Development the US Environmental Protection Agency’s Medaka Extended One Generation Reproduction Test (MEOGRT) Using Data from Nine Multigenerational Medaka Tests
U.S. Environmental Protection Agency —
In response to various legislative mandates the United States Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which... -
Federal
High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
U.S. Environmental Protection Agency —
Repository for supplemental files and code for paper titled "High-throughput AR Dimerization Assay Identifies Androgen Disrupting Chemicals and Metabolites", 2022.... -
Federal
Case study in 21st century ecotoxicology: using in vitro aromatase inhibition data to predict short term in vivo responses in adult female fish
U.S. Environmental Protection Agency —
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal... -
Federal
Predicting Estrogenicity of a Group of Substituted Phenols_IATA
U.S. Environmental Protection Agency —
Data are summarized in a two-dimensional data matrix that was developed for each substance for hazard characterization (Tables S1–S3). In the horizontal direction of... -
Federal
Case study in 21st century ecotoxicology: Using in vitro aromatase inhibition data to predict reproductive outcomes in fish, in vivo.
U.S. Environmental Protection Agency —
Data set includes empirical results from 60 h, 10 d, and 21 d exposures of female fathead minnows to the fungicide imazalil as well as simulations from predictive... -
Federal
Bioactive Contaminants of Emerging Concern in National Park Waters of the Northern Colorado Plateau, USA
U.S. Environmental Protection Agency —
Water and sediment was collected to assess the occurrence of contaminants of emerging concern (CECs) in National Park waters of the northern Colorado Plateau, USA.... -
Federal
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium
U.S. Environmental Protection Agency —
Datasets used in ORD-023417: Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium. This dataset is associated with the... -
Federal
A study of temporal effects of the model anti-androgen flutamide on components of the hypothalamic-pituitary-gonadal axis in adult fathead minnows
U.S. Environmental Protection Agency —
The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal axis of fathead minnow treated with the model androgen receptor (AR)... -
Federal
Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17beta-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas).
U.S. Environmental Protection Agency —
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and... -
Federal
Organic contaminants, including hormones, pesticides, pharmaceuticals and other endocrine disrupting compounds, and estrogenicity data in select surface water samples as well as organic contaminants in bed sediment samples collected in Chesapeake Bay watershed in parts of Maryland, Pennsylvania, and West Virginia, 2012-2018 (ver. 2.0, August 2020)
Department of the Interior —
These data represent surface water and bed sediment samples analyzed for a variety of organic compounds. The samples were collected in streams and rivers in the... -
Federal
Dataset and code for cross species applicability of an AOP network for thyroid hormone system disruption
U.S. Environmental Protection Agency —
The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database... -
Federal
Effects of metformin and its metabolite guanylurea on fathead minnow (Pimephales promelas) reproduction
U.S. Environmental Protection Agency —
Data associated with exposures of fathead minnows to varying concentrations of metformin and/or guanylurea. Includes three individual studies: ex vivo steroidogenesis... -
Federal
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
U.S. Environmental Protection Agency —
Supplementary data for "Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung, Sigmund J. Degitz, Assessing utility of thyroid in vitro... -
Federal
Gonadal Development in Smallmouth Bass (Micropterus Dolomieu) Reared in the Absence and Presence of 17-α-Ethinylestradiol
U.S. Environmental Protection Agency —
Supporting information for "Kadlec, S.M., Blackwell, B.R., Blanksma, C.A., Johnson, R.D., Olker, J.H., Schoff, P.K. and Mount, D.R. (2022), Gonadal Development in... -
Federal
“The influence of control group reproduction on the statistical power of the Environmental Protection Agency’s Medaka Extended One Generation Reproduction Test (MEOGRT) data for simulations” Dataset
U.S. Environmental Protection Agency —
Excel spreadsheet that contains the raw fecundity data used to conduct power simulations specific to the MEOGRT reproductive assessment. This dataset is associated... -
Federal
Effects of deiodinase inhibition on amphibian metamorphosis
U.S. Environmental Protection Agency —
This dataset contains in vitro and in vivo biochemical and apical (i.e., growth/development) data pertaining to iodotyrosine deiodinase inhibition in the African...
75 datasets found