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Phenone rtER binding Vtg_Tapper_A-jm6n_data set 20171002

Metadata Updated: November 12, 2020

Phenones and hydroxy benzophenones are widely used as UV radiation filters, and in the manufacturing of insecticides and pharmaceuticals. Understanding the ability of these chemicals to mimic the effects of the steroid estrogen is of interest to the US Environmental Protection Agency and other international environmental organizations. The current study sequentially combined complementary in vitro (outside a living organism) rainbow trout estrogen receptor (rtER) binding and liver slice vitellogenin (Vtg) mRNA induction assays in the context of a defined ER-mediated adverse outcome pathway (AOP). Cyclic phenones, branched phenones, and hydroxybenzophenones bound to rtER with relative potency ranging from no affinity to high binding affinity of 0.11%, and many induced Vtg, an egg yolk protein, gene expression in rt liver slices. In addition, cyclohexylphenylketone which did not bind rtER binding in cytosol was biotransformed within liver tissue to a chemical that induced Vtg expression. Cyclic phenones, branched phenones and hydroxybenzophenones produced estrogen like responses in these rainbow trout in vitro assays.

This dataset is associated with the following publication: Tapper, M., J. Denny, J. Serrano, R. Kolanczyk, B. Sheedy, G. Overland, M. Hornung, and P. Schmieder. Phenone, hydroxybenzophenone, and branched phenone estrogen receptor binding and vitellogenin agonism in rainbow trout in vitro models. Applied In Vitro Toxicology. Mary Ann Liebert, Inc., Larchmont, NY, USA, 5(1): 62-74, (2019).

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Public: This dataset is intended for public access and use. License: See this page for license information.

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Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Data Last Modified 2018-03-07
Public Access Level public
Bureau Code 020:00
Schema Version
Harvest Object Id 58513651-c2fa-428b-92ee-24e944a86b07
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents
Source Datajson Identifier True
Source Hash 8b2bd2a8f3bbaa95e79ca68fc2c48b6378ba38cf
Source Schema Version 1.1

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