72 datasets found
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Federal
The thyroid hormone system disrupting potential of resorcinol in fish
U.S. Environmental Protection Agency —
Supplemental materials for "The thyroid hormone system disrupting potential of resorcinol in fish". This dataset is associated with the following publication: Van... -
Federal
A case study on the use of exposure-activity ratios (EARs) to prioritize sites, chemicals, and bioactivities of concern in Great Lakes waters
U.S. Environmental Protection Agency —
As a case study, chemical occurrence data from a 2012 study in the Great Lakes Basin along with the ToxCast™ effects database were used to calculate exposure-activity... -
Federal
The effect of thyroperoxidase and deiodinase inhibition on anterior swim bladder inflation in the zebrafish
U.S. Environmental Protection Agency —
The data set provides all data that were reported in results, tables, and figures associated with Stinckens et al., "The effect of thyroperoxidase and deiodinase... -
Federal
Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data
U.S. Environmental Protection Agency —
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were... -
Federal
Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase (CYP19) Activity Among 18 Freshwater Fishes
U.S. Environmental Protection Agency —
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic... -
Federal
Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays
U.S. Environmental Protection Agency —
Contaminant data from bald eagles in the Upper-Midwest of the US. Dataset contains five tables in total including details of sample collection locations, organic... -
Federal
Putative adverse outcome pathway development based on physiological responses of female fathead minnows to model estrogen versus androgen receptor agonists
U.S. Environmental Protection Agency —
"Morshead ML, Jensen KM, Ankley GT, Vliet S, LaLone CA, Aller AV, Watanabe KH, Villeneuve DL. Putative adverse outcome pathway development based on physiological... -
Federal
Bioactive Contaminants of Emerging Concern in National Park Waters of the Northern Colorado Plateau, USA
U.S. Environmental Protection Agency —
Water and sediment was collected to assess the occurrence of contaminants of emerging concern (CECs) in National Park waters of the northern Colorado Plateau, USA.... -
Federal
Potential toxicity of complex mixtures in surface waters from a nationwide survey of United States streams: Identifying in vitro bioactivities and causative chemicals
U.S. Environmental Protection Agency —
In vitro biological activity data from a extracts of a nationwide survey of US streams. This dataset is associated with the following publication: Blackwell, B., G.... -
Federal
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
U.S. Environmental Protection Agency —
Data from a large-scale modeling project called CERAPP (Collaborative Estrogen Receptor Activity Prediction Project) demonstrating using predictive computational... -
Federal
Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA
U.S. Environmental Protection Agency —
The datafile contains data associated with analytical chemistry, fish gene expression, in vitro bioassays, chemical prioritization, and Attagene data for surface... -
Federal
Predicting Estrogenicity of a Group of Substituted Phenols_IATA
U.S. Environmental Protection Agency —
Data are summarized in a two-dimensional data matrix that was developed for each substance for hazard characterization (Tables S1–S3). In the horizontal direction of... -
Federal
Adverse Outcome Pathway Networks II: Network Analytics
U.S. Environmental Protection Agency —
The data set provides a set of txt files and cytoscape files that were used to construct the example AOP networks included in the paper. Additionally, a supplementary... -
Federal
Challenges and Opportunities for Translational Research on Congenital Anomalies of External Genitalia: Summary of an NIDDK/AUA Workshop
U.S. Environmental Protection Agency —
This was a summary article from a workshop and did not produce new data. This dataset is not publicly accessible because: This was a summary article from a workshop... -
Federal
Data for Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish
U.S. Environmental Protection Agency —
The data set includes: 1) Swimbladder inflation at 120 hours post-fertilization (hpf) 2) Swimbladder surface area at 120 hpf 3) Larval body length at 120 hpf 4)... -
Federal
Larval fathead minnow swim bladder inflation following exposure to 2-mercaptobenzothiazole
U.S. Environmental Protection Agency —
In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was... -
Federal
Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library
U.S. Environmental Protection Agency —
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist... -
Federal
Year-round presence of neonicotinoid insecticides in tributaries to the Great Lakes, USA
U.S. Environmental Protection Agency —
To better understand the transport of neonicotinoid insecticides into the Great Lakes, monthly samples (October 2015-September 2016) were collected from 10... -
Federal
Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA)
U.S. Environmental Protection Agency —
Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using... -
Federal
Effects of metformin and its metabolite guanylurea on fathead minnow (Pimephales promelas) reproduction
U.S. Environmental Protection Agency —
Data associated with exposures of fathead minnows to varying concentrations of metformin and/or guanylurea. Includes three individual studies: ex vivo steroidogenesis...
72 datasets found