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    • Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA)

    Metadata Updated: June 15, 2025

    Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using the Larval Amphibian Growth and Development Assay (LAGDA) to investigate endocrine-mediated effects. A delay in development to NF stage 62 was observed for the three chemicals, however, histopathological evaluation revealed that the effects were likely not thyroid related. 4-NP caused increased stage scores in male and female gonadal duct development. Citation information for this dataset can be found in Data.gov's References section.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: See this page for license information.

    Downloads & Resources

    References

    https://pasteur.epa.gov/uploads/10.23719/1532344/documents/Supplemental%20Spreadsheet%20S1%20a-c.xlsx

    Dates

    Metadata Created Date June 15, 2025
    Metadata Updated Date June 15, 2025

    Metadata Source

    Harvested from EPA ScienceHub

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date June 15, 2025
    Metadata Updated Date June 15, 2025
    Publisher U.S. Environmental Protection Agency
    Maintainer
    Identifier https://doi.org/10.23719/1532344
    Data Last Modified 2025-06-09
    Public Access Level public
    Bureau Code 020:00
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Harvest Object Id 4b530355-b007-4bcd-81d4-a43e698878c2
    Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
    Harvest Source Title EPA ScienceHub
    License https://pasteur.epa.gov/license/sciencehub-license.html
    Program Code 020:000
    Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency
    Related Documents https://pasteur.epa.gov/uploads/10.23719/1532344/documents/Supplemental%20Spreadsheet%20S1%20a-c.xlsx
    Source Datajson Identifier True
    Source Hash 52ff81ab94c0161a50325add603e9b8e465aba3b93645a0a632c7011232c099e
    Source Schema Version 1.1

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