Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA)
Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using the Larval Amphibian Growth and Development Assay (LAGDA) to investigate endocrine-mediated effects. A delay in development to NF stage 62 was observed for the three chemicals, however, histopathological evaluation revealed that the effects were likely not thyroid related. 4-NP caused increased stage scores in male and female gonadal duct development. Citation information for this dataset can be found in Data.gov's References section.
Resources
3 resources available
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Larval Amphibian Growth and Development Assay (LAGDA) of 2-Ethylhexyl 4-Hydroxybenzoate .docx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT -
Larval Amphibian Growth and Development Assay (LAGDA) of 4-nonylphenol.docx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT -
Larval Amphibian Growth and Development Assay (LAGDA) of Triclosan.docx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.WORDPROCESSINGML.DOCUMENT
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Alaa Kamel", "hasEmail": "mailto:kamel.alaa@epa.gov" } |
| description | Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using the Larval Amphibian Growth and Development Assay (LAGDA) to investigate endocrine-mediated effects. A delay in development to NF stage 62 was observed for the three chemicals, however, histopathological evaluation revealed that the effects were likely not thyroid related. 4-NP caused increased stage scores in male and female gonadal duct development. Citation information for this dataset can be found in Data.gov's References section. |
| distribution |
[ { "title": "Larval Amphibian Growth and Development Assay (LAGDA) of 2-Ethylhexyl 4-Hydroxybenzoate .docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%202-Ethylhexyl%204-Hydroxybenzoate%20.docx" }, { "title": "Larval Amphibian Growth and Development Assay (LAGDA) of 4-nonylphenol.docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%204-nonylphenol.docx" }, { "title": "Larval Amphibian Growth and Development Assay (LAGDA) of Triclosan.docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%20Triclosan.docx" } ] |
| identifier | https://doi.org/10.23719/1532344 |
| keyword |
[ "2-Ethylhexyl 4-Hydroxybenzoate", "4-nonylphenol", "LAGDA", "Triclosan", "Xenopus", "amphibian", "endocrine disruption" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2025-06-09 |
| programCode |
[ "020:000" ] |
| publisher |
{ "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } |
| references |
[ "https://pasteur.epa.gov/uploads/10.23719/1532344/documents/Supplemental%20Spreadsheet%20S1%20a-c.xlsx" ] |
| rights |
null
|
| title | Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA) |
