Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Skip to content

Defining the Taxonomic Domain of Applicability for Mammalian-Based High-Throughput Screening Assays

Metadata Updated: November 12, 2020

Final Data SeqAPASS contains datasets from Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool versions 3.0 for all 497 proteins evaluated using Level 1 (primary amino acid sequence comparisons) and Level 2 (functional domain(s) sequence comparisons) to understand conservation of HTS targets across species. Each folder is labeled by the protein accession (identification number and SeqAPASS version), with subfolders containing Level 1 and Level 2 output from the SeqAPASS tool. SeqAPASS v3.0 Data in Assay Contains all SeqAPASS data sorted by ToxCast Assay Group (as described in manuscript materials and methods). The original SeqAPASS data for each assay group are found in the folders titled Cell Adhesion, Cytochrome P450, Cytokine, DNA Binding, Esterase, G protein-coupled receptor, Growth Factor, Hydrolase, Ion Channel, Kinase, Lyase, Methyltransferase, Nuclear Receptor, Oxidoreductase, Phophatase, Protease, Protease Inhibitor, and Transporter. The Data_L1_Output folders and Data_L2_Output folders provide summaries of the Level 1 and Level 2 data comparing across datasets (See manuscript Supplemental Data, Legend for further details).

This dataset is associated with the following publication: LaLone, C., D. Villeneuve, J. Doering, B. Blackwell, T. Transue, C. Simmons, J. Swintek, S. Degitz, A. Williams, and G. Ankley. Defining the taxonomic domain of applicability for mammalian-based high-throughput screening assays.. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(23): 13960-13971, (2018).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources



Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Data Last Modified 2018-04-09
Public Access Level public
Bureau Code 020:00
Schema Version
Data Dictionary
Data Dictionary Type application/vnd.openxmlformats-officedocument.wordprocessingml.document
Harvest Object Id c05f5f94-60ac-4dfb-9280-e7164323a9bb
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents
Source Datajson Identifier True
Source Hash a2e4349369d766cca32ca8e1dd2c122466ef5f11
Source Schema Version 1.1

Didn't find what you're looking for? Suggest a dataset here.