42 datasets found
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Federal
Defining the Taxonomic Domain of Applicability for Mammalian-Based High-Throughput Screening Assays
U.S. Environmental Protection Agency —
Final Data SeqAPASS v3.0.zip contains datasets from Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool versions 3.0 for all 497 proteins... -
Federal
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and Gene Expression in the Ovary of Female Fathead Minnows (Pimephales promelas)
U.S. Environmental Protection Agency —
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect... -
Federal
Bioactive Contaminants of Emerging Concern in National Park Waters of the Northern Colorado Plateau, USA
U.S. Environmental Protection Agency —
Water and sediment was collected to assess the occurrence of contaminants of emerging concern (CECs) in National Park waters of the northern Colorado Plateau, USA.... -
Federal
The effect of thyroperoxidase and deiodinase inhibition on anterior swim bladder inflation in the zebrafish
U.S. Environmental Protection Agency —
The data set provides all data that were reported in results, tables, and figures associated with Stinckens et al., "The effect of thyroperoxidase and deiodinase... -
Federal
Case study in 21st century ecotoxicology: using in vitro aromatase inhibition data to predict short term in vivo responses in adult female fish
U.S. Environmental Protection Agency —
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal... -
Federal
Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17beta-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas).
U.S. Environmental Protection Agency —
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and... -
Federal
Integrative computational approaches to inform relative bioaccumulation potential of per- and polyfluoroalkyl substances (PFAS) across species
U.S. Environmental Protection Agency —
Datasets included in the entry are Results from the US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool and... -
Federal
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas)"
U.S. Environmental Protection Agency —
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation... -
Federal
Pilot testing and optimization of a larval fathead minnow high throughput transcriptomics assay
U.S. Environmental Protection Agency —
The present study describes pilot testing of a high throughput compatible transcriptomics assay with larval fathead minnows. One day post hatch fathead minnows were... -
Federal
Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
U.S. Environmental Protection Agency —
Table of contents Table S1 DNT inventory List of sources and associated data collected for the development of the Bayesian hierarchical model. Table S2 Data... -
Federal
Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase (CYP19) Activity Among 18 Freshwater Fishes
U.S. Environmental Protection Agency —
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic... -
Federal
Conversion of environmental estrone to estradiol by male fathead minnows
U.S. Environmental Protection Agency —
This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations... -
Federal
Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays
U.S. Environmental Protection Agency —
Contaminant data from bald eagles in the Upper-Midwest of the US. Dataset contains five tables in total including details of sample collection locations, organic... -
Federal
Year-round presence of neonicotinoid insecticides in tributaries to the Great Lakes, USA
U.S. Environmental Protection Agency —
To better understand the transport of neonicotinoid insecticides into the Great Lakes, monthly samples (October 2015-September 2016) were collected from 10... -
Federal
Toward an AOP Network-based tiered testing strategy for the assessment of thyroid hormone disruption
U.S. Environmental Protection Agency —
No novel data were reported in association with this product. This dataset is not publicly accessible because: The associated publication is a review/forum-type... -
Federal
Identifying chemicals and mixtures of potential biological concern detected in passive samplers from Great Lakes tributaries using high-throughput data and biological pathways
U.S. Environmental Protection Agency —
Water-borne contaminants were monitored in 69 tributaries of the Laurentian Great Lakes in 2010 and 2014 using semipermeable membrane devices (SPMDs), and polar... -
Federal
Effects-based monitoring of bioactive contaminants discharged to the Colorado River before and after a municipal wastewater treatment facility replacement
U.S. Environmental Protection Agency —
The present study highlights the utility of bioeffects-based monitoring in conjunction with analytical chemical measurements of surface waters on the Colorado River... -
Federal
Maumee River 2012 and 2016
U.S. Environmental Protection Agency —
The Maumee River and associated tributaries are an example of a system influenced by a mosaic of contaminant inputs from point and nonpoint sources along a gradient... -
Federal
Male Fathead Minnow Transcriptomes and Associated Chemical Analytes in Milwaukee Estuary System
U.S. Environmental Protection Agency —
This dataset presents the full hepatic transcriptomes of fathead minnows (Pimephales promelas) caged for four days at multiple sites within the Milwaukee Estuary area... -
Federal
Differentiating Pathway-Specific From Nonspecific Effects in High-Throughput Toxicity Data: A Foundation for Prioritizing Adverse Outcome Pathway Development
U.S. Environmental Protection Agency —
Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations...
42 datasets found