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Federal
Defining the Biologically Plausible Taxonomic Domain of Applicability of an Adverse Outcome Pathway: A Case Study Linking Nicotinic Acetylcholine Receptor Activation to Colony Death
U.S. Environmental Protection Agency —
Supporting Information for "Jensen, M.A., Blatz, D.J. and LaLone, C.A. (2023), Defining the Biologically Plausible Taxonomic Domain of Applicability of an Adverse... -
Federal
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas)"
U.S. Environmental Protection Agency —
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation... -
Federal
Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of metamorphic success in model amphibian Xenopus laevis
U.S. Environmental Protection Agency —
These data are represented in tables and graphs in the article, "Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine... -
Federal
Male Fathead Minnow Transcriptomes and Associated Chemical Analytes in Milwaukee Estuary System
U.S. Environmental Protection Agency —
This dataset presents the full hepatic transcriptomes of fathead minnows (Pimephales promelas) caged for four days at multiple sites within the Milwaukee Estuary area... -
Federal
AOP-Wiki Event Component Annotation
U.S. Environmental Protection Agency —
This dataset contains ontology terms associated with key events from the AOP-Wiki. This information was used to seed the AOP-Wiki with a carefully selected set of... -
Federal
Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays
U.S. Environmental Protection Agency —
Contaminant data from bald eagles in the Upper-Midwest of the US. Dataset contains five tables in total including details of sample collection locations, organic... -
Federal
Derivation and Evaluation of Putative Adverse Outcome Pathways for Effects of Cycylooxygenase inhibitors on Reproductive Processes in Female Fish
U.S. Environmental Protection Agency —
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme... -
Federal
Prior knowledge-based approach for associating contaminants with biological effects: a case study in the St. Croix river basin, MN, WI, USA.
U.S. Environmental Protection Agency —
Concentrations of 127 organic chemicals measured in water samples collected from five locations in proximity to two municipal wastewater treatment plants in the St.... -
Federal
Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA
U.S. Environmental Protection Agency —
The datafile contains data associated with analytical chemistry, fish gene expression, in vitro bioassays, chemical prioritization, and Attagene data for surface... -
Federal
The effect of thyroperoxidase and deiodinase inhibition on anterior swim bladder inflation in the zebrafish
U.S. Environmental Protection Agency —
The data set provides all data that were reported in results, tables, and figures associated with Stinckens et al., "The effect of thyroperoxidase and deiodinase... -
Federal
A study of temporal effects of the model anti-androgen flutamide on components of the hypothalamic-pituitary-gonadal axis in adult fathead minnows
U.S. Environmental Protection Agency —
The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal axis of fathead minnow treated with the model androgen receptor (AR)... -
Federal
Case study in 21st century ecotoxicology: using in vitro aromatase inhibition data to predict short term in vivo responses in adult female fish
U.S. Environmental Protection Agency —
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal... -
Federal
Raw Data for Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis
U.S. Environmental Protection Agency —
Supplementary Files 1-15 contain the generated assay data that was used to establish BMAD and determine treatment effects. The tabbed spreadsheet data is formatted so... -
Federal
An Integrated Approach for Identifying Priority Contaminant in the Great Lakes Basin –Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary Areas of Concern
U.S. Environmental Protection Agency —
Prioritization of chemicals was performed on two Areas of Concerns in the Great Lakes An integrated risk surveillance and monitoring approach was applied Bio-effect... -
Federal
SEQUENCING AND DE NOVO DRAFT ASSEMBLIES OF A FATHEAD MINNOW (Pimpehales promelas) reference genome
U.S. Environmental Protection Agency —
The dataset provides the URLs for accessing the genome sequence data and two draft assemblies as well as fathead minnow genotyping data associated with estimating the... -
Federal
Adverse outcome pathway (AOP) development and weight of evidence evaluation as illustrated by ecological case studies using online tools such as ECOTOX and SeqAPASS
U.S. Environmental Protection Agency —
The majority of this dataset includes the query output from online databases ECOTOX and SeqAPASS used to support the ecological AOP case studies described within the... -
Federal
Hypothetical Aggregate Exposure Pathway Network
U.S. Environmental Protection Agency —
This data set contains R code for a hypothetical exposure model described in the manuscript "A quantitative source-to-outcome case study to demonstrate the... -
Federal
Fathead minnow whole-mount in situ hybridization (WISH)
U.S. Environmental Protection Agency —
This study demonstrates the potential of whole-mount in situ hybridization (WISH), in conjunction with quantitative real-time polymerase chain reaction (QPCR) assays,... -
Federal
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and Gene Expression in the Ovary of Female Fathead Minnows (Pimephales promelas)
U.S. Environmental Protection Agency —
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect...