Search datasets
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The EPA has developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Since...
Search relevance: 1.00 | Views last month: 37 | Catalog Last Checked: April 21, 2026 at 08:01 PM -
Ongoing honey bee colony losses are of significant international concern because of the essential role these insects play in pollinating many high nutrient crops, such as fruits, vegetables, and...
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The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation for the three different CRISPR...
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The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal axis of fathead minnow treated with the model androgen receptor (AR) antagonist, flutamide....
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: April 21, 2026 at 07:57 PM -
Datasets included in the entry are Results from the US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool and from the molecular modeling...
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This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations would result in elevated plasma...
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Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
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computational chemistry data (very complex; need to be an expert to understand and use. This dataset is associated with the following publication: Lee, S., and M. Barron. 3D-QSAR Study of...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: April 21, 2026 at 07:57 PM -
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme activity in ovary, prostaglandin...
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Results from Quantitative Interspecies Thermal Shift Assay (QITSA) and molecular docking. This dataset is associated with the following publication: Han, J., J. Fu, J. Sun, D.R. Hall, D. Yang,...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: April 21, 2026 at 08:02 PM -
As a case study, chemical occurrence data from a 2012 study in the Great Lakes Basin along with the ToxCast™ effects database were used to calculate exposure-activity ratios (EARs) as a...
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These data are represented in tables and graphs in the article, "Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of...
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This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo) responses to...
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A data set of 500 chemicals evaluated for their ability to induce cleft palate in animal prenatal developmental studies was compiled from Toxicity Reference Database and the biomedical literature,...
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There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the...
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The datafile contains data associated with analytical chemistry, fish gene expression, in vitro bioassays, chemical prioritization, and Attagene data for surface water monitoring and caged fish...
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To better understand the transport of neonicotinoid insecticides into the Great Lakes, monthly samples (October 2015-September 2016) were collected from 10 tributaries to the Great Lakes, USA. At...
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In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in experiments in which...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: April 21, 2026 at 07:55 PM -
The microarray experiments used in the study. This dataset is associated with the following publication: Hill, T., J. Rooney, J. Abedini, H. El-Masri, C. Wood, and J. Corton. Gene Expression...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: April 21, 2026 at 08:00 PM -
A set of three proposed "hub" key events were used to link together a series of example adverse outcome pathway (AOP) descriptions that were previously not linked in an AOP network. While there...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: April 21, 2026 at 07:58 PM
