Search datasets
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The EPA has developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Since...
Search relevance: 1.00 | Views last month: 37 | Catalog Last Checked: September 10, 2026 at 06:57 PM -
A data set of 500 chemicals evaluated for their ability to induce cleft palate in animal prenatal developmental studies was compiled from Toxicity Reference Database and the biomedical literature,...
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The present study highlights the utility of bioeffects-based monitoring in conjunction with analytical chemical measurements of surface waters on the Colorado River associated with a historically...
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This dataset contains ontology terms associated with key events from the AOP-Wiki. This information was used to seed the AOP-Wiki with a carefully selected set of ontology terms prior to opening...
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This study demonstrates the potential of whole-mount in situ hybridization (WISH), in conjunction with quantitative real-time polymerase chain reaction (QPCR) assays, to examine the mechanistic...
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Datasets included in the entry are Results from the US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool and from the molecular modeling...
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The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal axis of fathead minnow treated with the model androgen receptor (AR) antagonist, flutamide....
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Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme activity in ovary, prostaglandin...
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Supporting Information for "Jensen, M.A., Blatz, D.J. and LaLone, C.A. (2023), Defining the Biologically Plausible Taxonomic Domain of Applicability of an Adverse Outcome Pathway: A Case Study...
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These data are represented in tables and graphs in the article, "Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of...
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The dataset provides the URLs for accessing the genome sequence data and two draft assemblies as well as fathead minnow genotyping data associated with estimating the heterozygosity of the in-bred...
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This data set contains R code for a hypothetical exposure model described in the manuscript "A quantitative source-to-outcome case study to demonstrate the integration of human health and...
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A collection of R scripts useful for extracting and analyzing adverse outcome pathway network data from the adverse outcome pathway wiki (aopwiki.org). This dataset is associated with the...
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The fathead minnow (Pimephales promelas) is a laboratory model organism widely used in regulatory toxicity testing and ecotoxicology research. Despite, the wealth of toxicological data for this...
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Final Data SeqAPASS v3.0.zip contains datasets from Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool versions 3.0 for all 497 proteins evaluated using Level 1 (primary...
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Predictive models and frameworks for linking inhibition of the enzyme aromatase, as measured in non-animal high throughput screening assays, to adverse effects on reproduction in fish have been...
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Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
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A set of three proposed "hub" key events were used to link together a series of example adverse outcome pathway (AOP) descriptions that were previously not linked in an AOP network. While there...
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Prioritization of chemicals was performed on two Areas of Concerns in the Great Lakes An integrated risk surveillance and monitoring approach was applied Bio-effect prediction methodologies were...
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We examined whether contaminants present in surface waters could be prioritized for further assessment by linking the presence of specific chemicals to gene expression changes in exposed fish....
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: September 10, 2026 at 06:53 PM
