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    • mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity

    Metadata Updated: December 6, 2023

    DLD-1 and MOLT-4 cell lines were cultured in a Rotating cell culture system to simulate microgravity and mRNA expression profile was observed in comparison to Static controls. Cells were grown in 10mL rotating vessels in an RCCS and in 60mm Petri dishes (test control respectively).Two replicates of test (Microgravity) and control (static) each from DLD-1 and MOLT-4 were analyzed by microarray. Simulated microgravity affected the solid tumor cell line DLD-1 markedly which showed a higher percentage of dysregulated genes compared to the hematological tumor cell line MOLT-4. Microgravity affects the cell cycle of DLD-1 cells and disturbs expression of cell cycle regulatory gene networks. Multiple microRNA host genes were dysregulated and significantly mir-22 tumor suppressor microRNA is highly upregulated in DLD-1.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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    Dates

    Metadata Created Date January 31, 2023
    Metadata Updated Date December 6, 2023
    Data Update Frequency irregular

    Metadata Source

    Harvested from NASA Data.json

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date January 31, 2023
    Metadata Updated Date December 6, 2023
    Publisher National Aeronautics and Space Administration
    Maintainer
    Identifier nasa_genelab_GLDS-125_fway-due9
    Data First Published 2018-06-26
    Data Last Modified 2023-01-26
    Category Earth Science
    Public Access Level public
    Data Update Frequency irregular
    Bureau Code 026:00
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Metadata Catalog ID https://data.nasa.gov/data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 375d3c2c-25c6-4896-850d-a4d044036972
    Harvest Source Id 58f92550-7a01-4f00-b1b2-8dc953bd598f
    Harvest Source Title NASA Data.json
    Homepage URL https://data.nasa.gov/d/fway-due9
    Program Code 026:005
    Source Datajson Identifier True
    Source Hash 1505ea9ef04c89c89b8690c81c35263a05459672ece9d34b595d9f4fb9ffded4
    Source Schema Version 1.1

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