76 datasets found
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Federal
Proton irradiation augments the reduction in tumor progression observed with advanced age
National Aeronautics and Space Administration —
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have... -
Federal
MicroRNA expression of C. elegans in space environment
National Aeronautics and Space Administration —
Entire microRNA expression were analyzed using the Filgen Array miRNA Caenorhabditis elegans 232 probes (Filgen). In the microRNA expression analysis we compared the... -
Federal
Microgravity effect on C. elegans N2/VC (CERISE 4 days)
National Aeronautics and Space Administration —
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese... -
Federal
Spaceflight effects on the mouse retina: Histological gene expression and epigenetic changes after flight on STS-135
National Aeronautics and Space Administration —
We report the findings of an animal experiment onboard STS-135 investigating the molecular aspects of the impact of spaceflight on retinal biology by performing... -
Federal
Microgravity effect on C. elegans N2/VC (CERISE 4 days)
National Aeronautics and Space Administration —
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese... -
Federal
Biological Research in Canisters-16 (BRIC-16): Investigations of the plant cytoskeleton in microgravity with gene profiling and cytochemistry
National Aeronautics and Space Administration —
These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight... -
Federal
Galactic cosmic radiation induces stable epigenome alterations relevant to human lung cancer
National Aeronautics and Space Administration —
Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR) and in... -
Federal
Spaceflight effects on the mouse retina: Histological gene expression and epigenetic changes after flight on STS-135
National Aeronautics and Space Administration —
We report the findings of an animal experiment onboard STS-135 investigating the molecular aspects of the impact of spaceflight on retinal biology by performing... -
Federal
Gene expression profiling in human fibroblast after low-LET irradiation
National Aeronautics and Space Administration —
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate... -
Federal
Biological Research in Canisters-16 (BRIC-16): Investigations of the plant cytoskeleton in microgravity with gene profiling and cytochemistry
National Aeronautics and Space Administration —
These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight... -
Federal
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO) at 5dpf for one day
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special... -
Federal
Comparative gene expression analysis in the Arabidopsis thaliana root apex using RNA-seq and microarray transcriptome profiles
National Aeronautics and Space Administration —
The root apex is an important section of the plant root involved in environmental sensing and cellular development. Analyzing the gene profile of root apex in diverse... -
Federal
Global DNA methylation profiling of radiation-induced rat mammary carcinomas
National Aeronautics and Space Administration —
To investigate DNA methylation patterns in rat mammary carcinomas induced by ionizing radiation. DNA methylation patterns were analyzed in radiation-induced rat... -
Federal
Action of microgravity on root development
National Aeronautics and Space Administration —
Arabidopsis were grown on horizontal or vertical clinostat for 4 8 or 12 days. Seedlings on horizontal clinostat were in simulated microgravity and seedlings on... -
Federal
Gene expression profiling of PBL in response to ionising radiation and modeled microgravity
National Aeronautics and Space Administration —
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis... -
Federal
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO) at 5dpf for one day
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special... -
Federal
MicroRNA expression of C. elegans in space environment
National Aeronautics and Space Administration —
Entire microRNA expression were analyzed using the Filgen Array miRNA Caenorhabditis elegans 232 probes (Filgen). In the microRNA expression analysis we compared the... -
Federal
The Heat-Inducible Transcription Factor HsfA2 Enhances Anoxia Tolerance in Arabidopsis
National Aeronautics and Space Administration —
Anoxia induces several heat shock proteins and a heat pre-treatment can acclimatize Arabidopsis seedlings to a subsequent anoxic treatment. In this work we analyzed... -
Federal
Dynamic gene expression response to altered gravity in human myelomonocytic U937 cells [parabolic]
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human myelomonocytic U937 cells in 20s and 5min microgravity and in hypergravity and compared expression profiles to... -
Federal
Transcription profiling of Arabidopsis seedings exposed to UV-B irradiation
National Aeronautics and Space Administration —
Interaction of COP1 and UVR8 which regulate UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis thaliana.
76 datasets found