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Federal
HTTK R Package v1.7 - Evaluation and Calibration of High-Throughput Predictions of Chemical Distribution to Tissues
U.S. Environmental Protection Agency —
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from... -
Federal
Using ToxCast data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure.
U.S. Environmental Protection Agency —
Background: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological... -
Federal
Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system
U.S. Environmental Protection Agency —
The ToxCast program has generated in vitro screening data on over a thousand chemicals to assess potential disruption of important biological processes and assist in... -
Federal
Simmons_DeGroot_Metabolism_mRNA_transfection_ApplInVitroTox_Data
U.S. Environmental Protection Agency —
The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS)... -
Federal
2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation
U.S. Environmental Protection Agency —
The objectives of this work were to: 1) develop an integrated analysis of chemical-mediated effects on steroidogenesis in the HT-H295R assay; and, 2) evaluate whether... -
Federal
Genesis and Study Design for EPA's Non-Targeted Analysis Collaborative Trial (ENTACT)
U.S. Environmental Protection Agency —
Detection by GC and LC for ENTACT chemicals and OPERA predicted physicochemical properties for manuscript Figures 3 and 4. This dataset is associated with the... -
Federal
Judson_RefChem_InVitro_Assays
U.S. Environmental Protection Agency —
This supplemental material describes two sets of methods; first, it briefly describes the process used to create the EPA’s LitDB database, and second, it describes... -
Federal
ATP BINDING CASSETTE SUB-FAMILY MEMBER 2 (ABCG2) AND XENOBIOTIC EXPOSURE DURING EARLY MOUSE EMBRYONIC STEM CELL DIFFERENTIATION
U.S. Environmental Protection Agency —
ATP binding cassette sub-family member 2 (ABCG2) is a well-defined efflux transporter found in various tissues. The role of ABCG2 during early embryonic development,... -
Federal
Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library
U.S. Environmental Protection Agency —
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist... -
Federal
Minimal_Set_of_In_Vitro_ER_Agonist_Assays_Selection_RegToxPharm_Data
U.S. Environmental Protection Agency —
A dataset for the manuscript which demonstrates that it is possible to achieve levels of performance equivalent to the full 16 assay ER agonist model against both in... -
Federal
Predicting_Systemic_Toxicity_Effects_ArchTox_2017_Data
U.S. Environmental Protection Agency —
In an effort to address a major challenge in chemical safety assessment, alternative approaches for characterizing systemic effect levels, a predictive model was... -
Federal
Non-Targeted Analysis of ENTACT Mixtures
U.S. Environmental Protection Agency —
Results from a non-targeted analysis of synthetic chemical mixtures. This dataset is associated with the following publication: Sobus, J., J. Grossman, A. Chao, R.... -
Federal
Structural alerts for protein binding
U.S. Environmental Protection Agency —
The JRC dataset (doi: 10.1016/j.tiv.2016.07.014) includes reported outcomes in chemico, in vitro and in vivo tests for skin sensitisation. The Tox21 dataset was... -
Federal
The ToxCast pipeline: updates to curve-fitting approaches and database structure
U.S. Environmental Protection Agency —
Supplemental files to accompany the manuscript: Feshuk et al., "The ToxCast Pipeline: Updates to Curve-fitting Approaches and Database Structure", DOI... -
Federal
Food, Beverage, and Feedstock Processing Facility Wastewater: a Unique and Underappreciated Source of Contaminants to U.S. Streams
U.S. Environmental Protection Agency —
PCA contribution of variables; stacked barplot of PFAS compounds by facility; detected concentrations and corresponding exposure–activity ratios; toxicity quotients... -
Federal
High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity
U.S. Environmental Protection Agency —
Dataset consists of high throughput in vitro bioactivity data and exposure predictions from the U.S. EPA’s Toxicity and Exposure Forecaster (ToxCast and ExpoCast)... -
Federal
Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data
U.S. Environmental Protection Agency —
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were... -
Federal
High-throughput screening of chemical effects on steroidogenesis using H295R human adrenocortical carcinoma cells
U.S. Environmental Protection Agency —
Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-... -
Federal
Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment
U.S. Environmental Protection Agency —
Table S1. All chemicals and AC50 from invitrodb v3 for human FACTORIAL-TRANS assay endpoints. Table S2. Agreement with OECD reference AR agonists. Table S3. Agreement... -
Federal
High-throughput Toxicogenomic Screening of Chemicals in the Environment Using Metabolically Competent, Human-derived Hepatic Cell Cultures
U.S. Environmental Protection Agency —
Gene expression data from the Fluidigm qRT-PCR arrays was analyzed in R (v3.6.1; R Foundation for Statistical Computing, 2019). Prior to processing through the tcpl...