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    • ATP BINDING CASSETTE SUB-FAMILY MEMBER 2 (ABCG2) AND XENOBIOTIC EXPOSURE DURING EARLY MOUSE EMBRYONIC STEM CELL DIFFERENTIATION

    Metadata Updated: October 25, 2021

    ATP binding cassette sub-family member 2 (ABCG2) is a well-defined efflux transporter found in various tissues. The role of ABCG2 during early embryonic development, however, is not established. Previous work suggested an association exists between xenobiotics that regulate Abcg2 transcription and differentiation of mouse embryonic stem cells (mESC), a relationship potentially related to redox homeostasis. ABCG2 was found to serve protective role in mESC as a xenobiotic transporter. The role of ABCG2 in regulating redox status, however, was unclear. The hypothesis that ABCG2 plays a fundamental role during mESC differentiation or that regulation of the receptor by xenobiotics may be associated with altered mESC differentiation could not be supported.

    This dataset is associated with the following publication: Rosen, M., S. Jeffay, H. Nichols, M. Hoopes, and S. Hunter. ATP Binding Cassette Sub-Family Member 2 (ABCG2) And Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, USA, 110(1): 35-47, (2017).

    Access & Use Information

    Public: This dataset is intended for public access and use. License: See this page for license information.

    Downloads & Resources

    References

    https://doi.org/10.1002/bdr2.1114

    Dates

    Metadata Created Date October 25, 2021
    Metadata Updated Date October 25, 2021

    Metadata Source

    Harvested from EPA ScienceHub

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date October 25, 2021
    Metadata Updated Date October 25, 2021
    Publisher U.S. EPA Office of Research and Development (ORD)
    Maintainer
    Identifier https://doi.org/10.23719/1377399
    Data Last Modified 2017-05-10
    Public Access Level public
    Bureau Code 020:00
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Harvest Object Id 02388568-02fb-4104-90c2-d3c927822976
    Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
    Harvest Source Title EPA ScienceHub
    License https://pasteur.epa.gov/license/sciencehub-license.html
    Program Code 020:095
    Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
    Related Documents https://doi.org/10.1002/bdr2.1114
    Source Datajson Identifier True
    Source Hash 782da544dbec0595afdcb3e94ef119aa2929f320
    Source Schema Version 1.1

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