29 datasets found
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Federal
Cancer Incidence - Surveillance, Epidemiology, and End Results (SEER) Registries Limited-Use
U.S. Department of Health & Human Services —
SEER Limited-Use cancer incidence data with associated population data. Geographic areas available are county and SEER registry. The Surveillance, Epidemiology, and... -
Federal
Data Table for Figures
U.S. Environmental Protection Agency —
This excel file contains 7 tabs, each tabs contains the data for one specific figure in the paper. Description of the data and column names is also provided in each... -
Federal
Dataset and code for cross species applicability of an AOP network for thyroid hormone system disruption
U.S. Environmental Protection Agency —
The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database... -
Federal
Characterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines
U.S. Environmental Protection Agency —
Biomarker Image Cytometry. The cell-level frequency of NK2 Homeobox 1 (NKX2-1), Keratin 7 (KRT7), and Thyroglobulin (TG) protein staining were quantitatively... -
Federal
Gestational Exposure to Perchlorate in the rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain
U.S. Environmental Protection Agency —
This dataset contains results from rodent study. Thyroid hormones and brain endpoints are reported for pregnant rat dams and progeny on gestational day 20 following... -
Federal
Raw data presented in manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the Postnatal Rat Brain" by O'Shaughnessy et al. 2024.
U.S. Environmental Protection Agency —
Raw data to accompanying manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the... -
Federal
Dataset_1: data in figures. Dataset_2: SI_Tables.
U.S. Environmental Protection Agency —
Dataset for the publication "Expanded High-Throughput Screening and Chemotype-Enrichment Analysis of the Phase II:e1k ToxCast Library for Human Sodium-Iodide... -
Federal
FRTL-5 RAIU of 5-AT
U.S. Environmental Protection Agency —
Iodide uptake following a two-hour incubation with concentrations of 5-ATcompared to control iodide uptake in FRTL thyroid follicular cells. This dataset is... -
Federal
DEVELOPMENT OF A SCREENING APPROACH TO DETECT THYROID DISRUPTING CHEMICALS THAT INHIBIT THE HUMAN SODIUM IODIDE SYMPORTER (NIS)
U.S. Environmental Protection Agency —
Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This dataset... -
Federal
Effects of Chronic Exposure to Triclosan on Reproductive and Thyroid Endpoints in the Adult Wistar Female Rat
U.S. Environmental Protection Agency —
This dataset includes the results of a long term adult female rat oral exposure to triclosan and includes hormone, estrous cyclicity, thyroid histology and liver gene... -
Federal
Data tables, and data used in figures presented in the manuscript "High-Throughput Screening and Chemotype-Enrichment Analysis of ToxCast Phase II Chemicals Evaluated for Human Sodium-Iodide Symporter (NIS) Inhibition"
U.S. Environmental Protection Agency —
All tables, plus the data for generating figures presented in the manuscript "High-Throughput Screening and Chemotype-Enrichment Analysis of ToxCast Phase II... -
Federal
Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents
U.S. Environmental Protection Agency —
Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the... -
Federal
Fetal and Postnatal Cortical Thyroid Hormone Levels and Bioindicators
U.S. Environmental Protection Agency —
thyroid hormones in serum and in brain were measured in fetal and neonatal rat cortex after graded levels of a thyroid hormone synthesis inhibitor were administered... -
Federal
Doc Title: Adult Hippocampal Neurogenesis is Impaired by Transient Developmental Thyroid Hormone Disruption
U.S. Environmental Protection Agency —
Severe thyroid hormone (TH) deprivation during development impairs neurogenesis throughout the brain. The hippocampus also maintains a capacity for neurogenesis... -
Federal
Data for "Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain"
U.S. Environmental Protection Agency —
Raw data accompanying "Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain". This dataset is... -
Federal
Secondary screening method for sodium-iodide symporter inhibition utilizing FRTL-5 cells data set
U.S. Environmental Protection Agency —
Data pertaining to a NIS-expressing cell line, FRTL-5 and it's screening capabilities for confirming inhibitors of NIS-mediated iodide uptake. This dataset is... -
Federal
Xenpous leavis deiodinase type 3 enzyme activity characterization and chemical screening data
U.S. Environmental Protection Agency —
Data set includes optimized assay parameters and kinetic characterization for xenopus laevis deiodinase type 3 enzyme, and inhibition activity of 352 ToxCast... -
Federal
Effects of deiodinase inhibition on amphibian metamorphosis
U.S. Environmental Protection Agency —
This dataset contains in vitro and in vivo biochemical and apical (i.e., growth/development) data pertaining to iodotyrosine deiodinase inhibition in the African... -
Federal
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
U.S. Environmental Protection Agency —
Supplementary data for "Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung, Sigmund J. Degitz, Assessing utility of thyroid in vitro... -
Federal
Impaired swim bladder inflation in early-life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid
U.S. Environmental Protection Agency —
The present study investigated whether inhibition of deiodinase, the enzyme which converts thyroxine (T4) to the more biologically-active form,...
29 datasets found