Xenpous leavis deiodinase type 3 enzyme activity characterization and chemical screening data
Data set includes optimized assay parameters and kinetic characterization for xenopus laevis deiodinase type 3 enzyme, and inhibition activity of 352 ToxCast chemicals against this enzyme.
This dataset is associated with the following publication:
Mayasich, S., J. Korte, J. Denny, P. Hartig, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, and M. Hornung. Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 73: 105141, (2021).
Resources
1 resource available
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200714_Mayasich_et_al_Xldio3 screening data.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Michael Hornung", "hasEmail": "mailto:hornung.michael@epa.gov" } |
| description | Data set includes optimized assay parameters and kinetic characterization for xenopus laevis deiodinase type 3 enzyme, and inhibition activity of 352 ToxCast chemicals against this enzyme. This dataset is associated with the following publication: Mayasich, S., J. Korte, J. Denny, P. Hartig, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, and M. Hornung. Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 73: 105141, (2021). |
| distribution |
[ { "title": "200714_Mayasich_et_al_Xldio3 screening data.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504033/200714_Mayasich_et_al_Xldio3%20screening%20data.xlsx" } ] |
| identifier | https://doi.org/10.23719/1504033 |
| keyword |
[ "Enzyme activity", "Xenopus", "deiodinase", "thyroid" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-06-19 |
| programCode |
[ "020:095" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1016/j.tiv.2021.105141" ] |
| rights |
null
|
| title | Xenpous leavis deiodinase type 3 enzyme activity characterization and chemical screening data |
