Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Male Rats
behavioral measures of learning and memory in adult offspring of rats treated with thyroid hormone synthesis inhibitor, propylthiouracil.
Electrophysiological measures of 'memory' in form of plasticity model known as long term potentiation (LTP)
Molecular changes induced by LTP.
This dataset is associated with the following publication:
Gilbert , M., K. Sanchez-Huerta, and C. Wood. Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Make Rats. ENDOCRINOLOGY. Endocrine Society, 157(2): 774-87, (2016).
Resources
1 resource available
-
M0710_BDNF LTP Data.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Mary Gilbert",
"hasEmail": "mailto:gilbert.mary@epa.gov"
}
|
| description | behavioral measures of learning and memory in adult offspring of rats treated with thyroid hormone synthesis inhibitor, propylthiouracil. Electrophysiological measures of 'memory' in form of plasticity model known as long term potentiation (LTP) Molecular changes induced by LTP. This dataset is associated with the following publication: Gilbert , M., K. Sanchez-Huerta, and C. Wood. Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Make Rats. ENDOCRINOLOGY. Endocrine Society, 157(2): 774-87, (2016). |
| distribution |
[
{
"title": "M0710_BDNF LTP Data.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/403/M0710_BDNF%20LTP%20Data.xlsx"
}
]
|
| identifier | A-v42b-403 |
| keyword |
[
"BDNF",
"CSS",
"LTP",
"activity-dependent plasticity",
"brain",
"brain development",
"children's health",
"developmental hypothyroidism",
"fear conditioning",
"hippocampus",
"neuroplasticity",
"neurotrophins",
"spatial learning",
"thyroid"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2015-10-27 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1210/en.2015-1643"
]
|
| rights |
null
|
| title | Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Male Rats |
