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Federal
MMartin_DFiler_tcpl: the ToxCast pipeline for high-throughput screening data recent views
U.S. Environmental Protection Agency —
The tcpl package provides a set of tools for processing and modeling high-throughput and high-content chemical screening data. This dataset is associated with the... -
Federal
Predict_Organ_Toxicity_ChemResTox_Data recent views
U.S. Environmental Protection Agency —
We use a supervised machine learning strategy to systematically investigate the relative importance of study type, machine learning algorithm, and type of descriptor... -
Federal
Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals recent views
U.S. Environmental Protection Agency —
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern.... -
Federal
Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program recent views
U.S. Environmental Protection Agency —
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the... -
Federal
Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library recent views
U.S. Environmental Protection Agency —
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist... -
Federal
Judson_RefChem_InVitro_Assays recent views
U.S. Environmental Protection Agency —
This supplemental material describes two sets of methods; first, it briefly describes the process used to create the EPA’s LitDB database, and second, it describes... -
Federal
Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space recent views
U.S. Environmental Protection Agency —
Chemical toxicity can arise from disruption of specific biomolecular functions or through more generalized cell stress and cytotoxicity-mediated processes. Here,... -
Federal
Data from Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors within the ToxCast Phase I and II Chemical Libraries recent views
U.S. Environmental Protection Agency —
High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that converge... -
Federal
Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data recent views
U.S. Environmental Protection Agency —
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were... -
Federal
High-throughput screening of chemical effects on steroidogenesis using H295R human adrenocortical carcinoma cells recent views
U.S. Environmental Protection Agency —
Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-... -
Federal
Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment recent views
U.S. Environmental Protection Agency —
Table S1. All chemicals and AC50 from invitrodb v3 for human FACTORIAL-TRANS assay endpoints. Table S2. Agreement with OECD reference AR agonists. Table S3. Agreement...