20 datasets found
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Federal
Saunders et al. Amended IVIVE model recent views
U.S. Environmental Protection Agency —
This paper described development of an in vitro/in vivo model that accounts for first pass clearance effects. The model details are contained in the supporting... -
Federal
Open source data summaries - Fish, Rat, and Goat Metabolism Studies recent views
U.S. Environmental Protection Agency —
Public versions of EFSA DAR's - metabolism study summaries for the pesticides; Fluazinam, Halauxifen-methyl, Kresoxim-methyl, Mandestrobin, Tolclofos-methyl in fish... -
Federal
Dataset for In vitro-in vivo extrapolation of hepatic biotransformation data for fish. III. An in-depth case study with pyrene. recent views
U.S. Environmental Protection Agency —
This dataset, presented as an Excel spreadsheet, contains all data presented as figures and tables in an article by Nichols et al, entitled "In vitro-in vivo... -
Federal
Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry recent views
U.S. Environmental Protection Agency —
Supplementary material for "Kreutz, A.; Clifton, M.S.; Henderson, W.M.; Smeltz, M.G.; Phillips, M.; Wambaugh, J.F.; Wetmore, B.A. Category-Based Toxicokinetic... -
Federal
PFAS Biotransformation Pathways: A Species Comparison Study recent views
U.S. Environmental Protection Agency —
Data for "Kolanczyk RC, Saley MR, Serrano JA, Daley SM, Tapper MA. PFAS Biotransformation Pathways: A Species Comparison Study. Toxics. 2023 Jan 12;11(1):74. doi:... -
Federal
Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation - data set recent views
U.S. Environmental Protection Agency —
Data set to support the manuscript "Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation". Contains analytical measurement of... -
Federal
Measurement of kinetic parameters for biotransformation of PAHs by trout liver S9 fractions: Implications for bioaccumulation assessment recent views
U.S. Environmental Protection Agency —
The dataset, which is presented as an Excel spreadsheet, contains all data which is presented as figures in Nichols et al., Measurement of kinetic parameters for... -
Federal
Allometric scaling of hepatic biotransformation in rainbow trout recent views
U.S. Environmental Protection Agency —
This dataset illustrates relationships between body weight and hepatic phase I and phase II metabolic activity in rainbow trout. This dataset is associated with the... -
Federal
Nichols et al._Biotransformation of PAH mixures by trout liver S9 fractions recent views
U.S. Environmental Protection Agency —
This Excel spreadsheet provides data that appear in Tables 1- 2 and Figures 1-4 of the main document, as well as data that appear in Figures S1-S3 of the... -
Federal
Metabolism of Diazinon in Rainbow Trout Liver Slices version 1 Tapper A-12jq 09122017 recent views
U.S. Environmental Protection Agency —
Understanding biotransformation pathways in aquatic species is an integral part of ecological risk assessment with respect to the potential bioactivation of chemicals... -
Federal
Characterization data for trout liver S9 fractions used by Droge et al to measure the in vitro intrinsic clearance of cationic surfactants recent views
U.S. Environmental Protection Agency —
This ScienceHub dataset provides characterization data for a pooled sample of trout liver S9 fractions that was used to study the in vitro intrinsic clearance of... -
Federal
Saunders et al_IVIVE paper_Science Hub_entry_08142020 recent views
U.S. Environmental Protection Agency —
The purpose of is this study was to evaluate the potential for biotransformation in the gastrointestinal tissues (GIT) of fish to impact chemical bioaccumulation. In... -
Federal
Results from Non-Targeted Analysis of 6:2 FTS degradation samples recent views
U.S. Environmental Protection Agency —
NTA output of 6:2 FTS microbial cultures Chu TAMU. This dataset is associated with the following publication: Yang, S., Y. Shi, M. Strynar, and K. Chu. Desulfonation... -
Federal
Saunders et al._Dietary bioaccumulation and biotransformation of hydrophobic organic sunscreen agents in rainbow trout recent views
U.S. Environmental Protection Agency —
Organic ultraviolet filters (UVFs; also known as sunscreen agents) used in personal care and consumer products can enter the aquatic environment via wastewater... -
Federal
Simmons_DeGroot_Metabolism_mRNA_transfection_ApplInVitroTox_Data recent views
U.S. Environmental Protection Agency —
The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS)... -
Federal
Reliability of in vitro methods used to measure intrinsic clearance of hydrophobic organic chemicals by fish: results of an international ring trial_Nichols et al._Science Hub entry_02232018 recent views
U.S. Environmental Protection Agency —
This paper describes the results of an international ring trial (round robin study) of in vitro methods used to measure chemical biotransformation in fish.... -
Federal
High-resolution Mass Spectrometry of Skin Mucus for Monitoring Physiological Impacts and Contaminant Biotransformation Products in Fathead Minnows Exposed to Wastewater Effluent recent views
U.S. Environmental Protection Agency —
High-resolution mass spectrometry is advantageous for monitoring physiological impacts and contaminant biotransformation products in fish exposed to complex... -
Federal
Comparison of cryopreserved trout hepatocytes and liver S9 fractions as in vitro tools for bioaccumulation assessment of chemicals that undergo biotransformation in fish recent views
U.S. Environmental Protection Agency —
The purpose of this study was to compare two in vitro systems, cryopreserved trout hepatocytes and trout liver S9 fractions, used to predict in vivo levels of... -
Federal
Black et al_human rat and trout CLint_ScienceHub entry recent views
U.S. Environmental Protection Agency —
This dataset provides measured in vitro intrinsic clearance rates for 54 chemicals tested using isolated hepatocytes from humans, rats, and rainbow trout. The test... -
Federal
Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates Require Accurate Estimates of Blood–Water Partitioning and Chemical Volume of Distribution recent views
U.S. Environmental Protection Agency —
Supporting information in "Saunders, L.J. and Nichols, J.W. (2023), Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates...
20 datasets found