Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation - data set
Data set to support the manuscript "Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation". Contains analytical measurement of metabolites, binding potential to the estrogen receptor, and gene activation to vitellogenin induction in the rainbow trout assays. Chemicals of interest in this study were phenolphthalein, phenolphthalin, and 4,4’-methylenedianiline.
This dataset is associated with the following publication:
Kolanczyk, R., J. Denny, B. Sheedy, V. Olson, J. Serrano, and M. Tapper. Increased Endocrine Activity of Xenobiotic Chemicals as Mediated by Metabolic Activation.. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 42(12): 2747-2757, (2023).
Resources
1 resource available
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ER Metabolism_data.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Richard Kolanczyk", "hasEmail": "mailto:kolanczyk.rick@epa.gov" } |
| description | Data set to support the manuscript "Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation". Contains analytical measurement of metabolites, binding potential to the estrogen receptor, and gene activation to vitellogenin induction in the rainbow trout assays. Chemicals of interest in this study were phenolphthalein, phenolphthalin, and 4,4’-methylenedianiline. This dataset is associated with the following publication: Kolanczyk, R., J. Denny, B. Sheedy, V. Olson, J. Serrano, and M. Tapper. Increased Endocrine Activity of Xenobiotic Chemicals as Mediated by Metabolic Activation.. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 42(12): 2747-2757, (2023). |
| distribution |
[ { "title": "ER Metabolism_data.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529119/ER%20Metabolism_data.xlsx" } ] |
| identifier | https://doi.org/10.23719/1529119 |
| keyword |
[ "Metabolism", "biotransformation", "estrogen receptor", "phenolphthalein", "phenolphthalin", "rainbow trout" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2023-06-06 |
| programCode |
[ "020:000" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1002/etc.5748" ] |
| rights |
null
|
| title | Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation - data set |
