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Federal
Judson_Kleinstreuer_Development and Validation of a Computational Model for Androgen Receptor Activity.
U.S. Environmental Protection Agency —
Data on 1855 chemicals were generated during ToxCast Phases I and II and Tox21 screening using 11 AR-related in vitro assays to build a computational network model... -
Federal
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories
U.S. Environmental Protection Agency —
All of the code used to analyze and report the data as well as build confidence in the approach is available as a supplementary RMarkdown report, and a tool to derive... -
Federal
Quantitative Structure-Use Relationship Model thresholds for Model Validation, Domain of Applicability, and Candidate Alternative Selection
U.S. Environmental Protection Agency —
This file contains value of the model training set confusion matrix, domain of applicability evaluation based on training set to predicted chemicals structural... -
Federal
Quantitative Structure-Use Relationship (QSUR) Model Descriptors
U.S. Environmental Protection Agency —
This data set contains ToxPrint finger prints for all chemicals in FUse that had QSAR-ready SMILES strings as well as select physicochemical properties from the... -
Federal
MMartin_DFiler_tcpl: the ToxCast pipeline for high-throughput screening data
U.S. Environmental Protection Agency —
The tcpl package provides a set of tools for processing and modeling high-throughput and high-content chemical screening data. This dataset is associated with the... -
Federal
Dataset for ORD-033364: Identification of Novel Activators of the Metal Responsive Transcription Factor (MTF-1) Using a Gene Expression Biomarker in a Microarray Compendium
U.S. Environmental Protection Agency —
The microarray experiments examined in the study. This dataset is associated with the following publication: Jackson, A., J. Liu, B. Vallanat, C. Jones, M. Nelms, G.... -
Federal
Dataset for 'Development of a bioprinter-based method for incorporating metabolic competence into high-throughput in vitro assays'
U.S. Environmental Protection Agency —
Data for Hopperstad K and Deisenroth C (2023) Development of a bioprinter-based method for incorporating metabolic competence into high-throughput in vitro assays.... -
Federal
Screening silver nanoparticles for potential neurotoxicity using cortical neurons grown on microelectrode arrays
U.S. Environmental Protection Agency —
the zip files contain outputs from the R-analysis for the nanosilver experiments. This dataset is associated with the following publication: Strickland, J., W. LeFew,... -
Federal
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
U.S. Environmental Protection Agency —
Supplementary data for "Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung, Sigmund J. Degitz, Assessing utility of thyroid in vitro... -
Federal
Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment
U.S. Environmental Protection Agency —
Supplemental data for "Schaupp CM, Maloney EM, Mattingly K, Olker JH, Villeneuve DL. Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a... -
Federal
Functional Use Database (FUse)
U.S. Environmental Protection Agency —
There are five different files for this dataset: 1. A dataset listing the reported functional uses of chemicals (FUse) 2. All 729 ToxPrint descriptors obtained from... -
Federal
The Alginate Immobilization of Metabolic Enzymes (AIME) Platform Retrofits an Estrogen Receptor Transactivation Assay with Metabolic Competence
U.S. Environmental Protection Agency —
The objective of this study was to develop an approach to retrofit existing HTS assays with hepatic metabolism. The Alginate Immobilization of Metabolic Enzymes... -
Federal
KPF_Examining the Utility of In Vitro Bioactivity as a Protective Point of Departure: A Case Study_APCRA
U.S. Environmental Protection Agency —
The files and .R scripts here are provided to aid in understanding and reproduction of the analyses in the submitted paper, "Examining the Utility of In Vitro... -
Federal
Development, validation and integration of in silico models to identify androgen active chemicals
U.S. Environmental Protection Agency —
A diverse data set of 1667 chemicals with AR experimental activity were provided by the U.S. EPA from the oxicity Forecaster (ToxCast) program which generates data... -
Federal
Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals
U.S. Environmental Protection Agency —
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern.... -
Federal
The Tox21 10K Compound Library: Part 1 - Collaborative chemistry advancing toxicology
U.S. Environmental Protection Agency —
Table S1: Tox21 IDs mapped to NCGC IDs, PubChem IDs, and DSSTox IDs, and indicating NCATS, NTP and EPA partner library associations (date stamped February 24, 2020).... -
Federal
Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program
U.S. Environmental Protection Agency —
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the... -
Federal
Pesticide Prioritization by Potential Biological Effects in Tributaries of the Laurentian Great Lakes
U.S. Environmental Protection Agency —
Data files for "Oliver, S.K., Corsi, S.R., Baldwin, A.K., Nott, M.A., Ankley, G.T., Blackwell, B.R., Villeneuve, D.L., Hladik, M.L., Kolpin, D.W., Loken, L., DeCicco,... -
Federal
Quantitative Structure-Use Relationship Model Predictions to evaluate Tox21 Chemicals as Functional Substitutes and Candidate Alternatives
U.S. Environmental Protection Agency —
This dataset provides a prediction for all Tox21 chemicals with available QSUR descriptors across all 41 valid QSUR models developed with FUse. This dataset is... -
Federal
Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries
U.S. Environmental Protection Agency —
These are the raw data files for TOXSCI manuscript 19-0578 entitled, “Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase...