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Federal
Male Fathead Minnow Transcriptomes and Associated Chemical Analytes in Milwaukee Estuary System
U.S. Environmental Protection Agency —
This dataset presents the full hepatic transcriptomes of fathead minnows (Pimephales promelas) caged for four days at multiple sites within the Milwaukee Estuary area... -
Federal
Toward an AOP Network-based tiered testing strategy for the assessment of thyroid hormone disruption
U.S. Environmental Protection Agency —
No novel data were reported in association with this product. This dataset is not publicly accessible because: The associated publication is a review/forum-type... -
Federal
First Generation Annotations for the Fathead Minnow (Pimephales promelas) Genome
U.S. Environmental Protection Agency —
The fathead minnow (Pimephales promelas) is a laboratory model organism widely used in regulatory toxicity testing and ecotoxicology research. Despite, the wealth of... -
Federal
Conversion of environmental estrone to estradiol by male fathead minnows
U.S. Environmental Protection Agency —
This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations... -
Federal
Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays
U.S. Environmental Protection Agency —
Contaminant data from bald eagles in the Upper-Midwest of the US. Dataset contains five tables in total including details of sample collection locations, organic... -
Federal
Prior knowledge-based approach for associating contaminants with biological effects: a case study in the St. Croix river basin, MN, WI, USA.
U.S. Environmental Protection Agency —
Concentrations of 127 organic chemicals measured in water samples collected from five locations in proximity to two municipal wastewater treatment plants in the St.... -
Federal
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas)"
U.S. Environmental Protection Agency —
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation... -
Federal
Case study in 21st century ecotoxicology: using in vitro aromatase inhibition data to predict short term in vivo responses in adult female fish
U.S. Environmental Protection Agency —
This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal... -
Federal
A case study on the use of exposure-activity ratios (EARs) to prioritize sites, chemicals, and bioactivities of concern in Great Lakes waters
U.S. Environmental Protection Agency —
As a case study, chemical occurrence data from a 2012 study in the Great Lakes Basin along with the ToxCast™ effects database were used to calculate exposure-activity... -
Federal
Rapid Effects of the Aromatase Inhibitor Fadrozole on Steroid Production and Gene Expression in the Ovary of Female Fathead Minnows (Pimephales promelas)
U.S. Environmental Protection Agency —
Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect... -
Federal
Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways
U.S. Environmental Protection Agency —
A set of three proposed "hub" key events were used to link together a series of example adverse outcome pathway (AOP) descriptions that were previously not linked in... -
Federal
Adverse Outcome Pathway Networks I: Development and Applications
U.S. Environmental Protection Agency —
In September, 2015, a water sample was collected downstream of a major metropolitan waste water treatment plant that discharges to the South Platte River, Colorado,... -
Federal
Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA
U.S. Environmental Protection Agency —
The datafile contains data associated with analytical chemistry, fish gene expression, in vitro bioassays, chemical prioritization, and Attagene data for surface... -
Federal
Maumee River 2012 and 2016
U.S. Environmental Protection Agency —
The Maumee River and associated tributaries are an example of a system influenced by a mosaic of contaminant inputs from point and nonpoint sources along a gradient... -
Federal
The effect of thyroperoxidase and deiodinase inhibition on anterior swim bladder inflation in the zebrafish
U.S. Environmental Protection Agency —
The data set provides all data that were reported in results, tables, and figures associated with Stinckens et al., "The effect of thyroperoxidase and deiodinase... -
Federal
Differentiating Pathway-Specific From Nonspecific Effects in High-Throughput Toxicity Data: A Foundation for Prioritizing Adverse Outcome Pathway Development
U.S. Environmental Protection Agency —
Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations... -
Federal
Assessing reproductive effects of aromatase inhibition on fishes with group-synchronous oocyte development using western mosquitofish (Gambusia affinis) as a model
U.S. Environmental Protection Agency —
Predictive models and frameworks for linking inhibition of the enzyme aromatase, as measured in non-animal high throughput screening assays, to adverse effects on... -
Federal
Quantitative response-response relationships linking aromatase inhibition to decreased fecundity are conserved across three fishes with asynchronous oocyte development
U.S. Environmental Protection Agency —
Data used in the creation of each figure and table cited in Doering et al. (2019; DOI: 10.1021/acs.est.9b02606) are provided. This dataset is associated with the... -
Federal
Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17beta-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas).
U.S. Environmental Protection Agency —
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and... -
Federal
Extracting and benchmarking emerging adverse outcome pathway knowledge
U.S. Environmental Protection Agency —
A collection of R scripts useful for extracting and analyzing adverse outcome pathway network data from the adverse outcome pathway wiki (aopwiki.org). This dataset...