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Accessing and distributing EMBL data using CORBA (common object request broker architecture)
Background: The EMBL Nucleotide Sequence Database is a comprehensive database of DNA and RNA sequences and related information traditionally made available in flat-file format.... -
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes
Background It has become increasingly clear that β-cell failure plays a critical role in the pathogenesis of type 2 diabetes. Free-radical mediated β-cell damage has been... -
PCR identification of
Trypanosoma (Herpetosoma) lewisi is a trypanosome of the sub-genus Herpetosoma (Stercoraria section), parasite of rats (Rattus rattus and Rattus norvegicus) transmitted by... -
Setting of graded levels of a protein in yeast by a t-degron technique as applied to phosphoglycerate mutase
Background Setting of graded levels of a protein for in vivo studies by controlled gene expression has inconveniences, and we here explore the use of the t-degron technique... -
The evaluation of yeast derivatives as adjuvants for the immune response to the Bm86 antigen in cattle
Background The Gavac™ vaccine against the cattle tick Boophilus microplus has proven its efficacy in a large number of controlled and field experiments. However, this vaccine... -
Synthesis of a novel hepatitis C virus protein by ribosomal frameshift
Hepatitis C virus (HCV) is an important human pathogen that affects ∼100 million people worldwide. Its RNA genome codes for a polyprotein, which is cleaved by viral and cellular... -
Conceptual framework of public health surveillance and action and its application in health sector reform
Background Because both public health surveillance and action are crucial, the authors initiated meetings at regional and national levels to assess and reform surveillance and... -
Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart
Background Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported that cardiac... -
A clustering method for repeat analysis in DNA sequences
Background A computational system for analysis of the repetitive structure of genomic sequences is described. The method uses suffix trees to organize and search the input... -
A functional update of the
Background Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and functions of... -
Endothelial [Ca2+]iis an integrating signal for the vascular tone in rat aortae
Although various endothelium-dependent relaxing factors (endothelial autacoids) are released upon the elevation of endothelial cytosolic free Ca2+concentration (EC [Ca2+]i), the... -
Clinical applicability of molecular biology: the case of the long QT syndrome
The clinical applicability of molecular cardiology has been questioned at length and by many clinical investigators. The congenital long QT syndrome (LQTS) provides an excellent... -
Socio-demographic factors and self-reported funtional status: the significance of social support
Background The aim of the present work was to investigate the relative importance of socio-demographic and physical health status factors for subjective functioning, as well as... -
Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions
Background The aim of this study was to determine and compare patients' and physicians' perceptions of benefits and risks of long term benzodiazepine use for insomnia in the... -
"Bronchial Artery Delivery of Viral Vectors for Gene delivery in Cystic Fibrosis; Superior to Airway Delivery?"
Background Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and... -
Regular use of aspirin and pancreatic cancer risk
Background Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma,... -
Bone loss: Quantitative imaging techniques for assessing bone mass in rheumatoid arthritis
Osteoporosis is associated with low bone mass and microarchitectural deterioration of bone tissue with clinical manifestation of low trauma fractures. Rheumatoid arthritis (RA)... -
Critical advances in septicemia and septic shock
Recent advances suggest that toll-like receptors, various cytokines, cicosanoids, free radicals and macrophage migration inhibitory factor (MIF) play an important role in the...
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