11 datasets found
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Federal
Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion
U.S. Department of Health & Human Services —
Mast cell (MC) activation in the rheumatoid lesion provides numerous mediators that contribute to inflammatory and degradative processes, especially at sites of... -
Federal
Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?
U.S. Department of Health & Human Services —
The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a... -
Federal
Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis
U.S. Department of Health & Human Services —
In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of... -
Federal
Post-transcriptional regulation of pro-inflammatory gene expression
U.S. Department of Health & Human Services —
The cytokine tumour necrosis factor (TNF)α is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in... -
Federal
Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-α by gallbladder epithelial cells: Response to bacterial lipopolysaccharides
U.S. Department of Health & Human Services —
Background In addition to immune cells, many other cell types are known to produce cytokines. Cultured normal mouse gallbladder epithelial cells, used as a model... -
Federal
Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kB.
U.S. Department of Health & Human Services —
Background Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of... -
Federal
TNF-α induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide
U.S. Department of Health & Human Services —
Background MAdCAM-1 is an adhesion molecule expressed in Peyer's patches and lymphoid tissues which is mobilized by cytokines like TNF-α and is a major determinant of... -
Federal
Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific
U.S. Department of Health & Human Services —
Background Previous studies have revealed that tumour necrosis factor (TNF)-α is upregulated in fibrosing alveolitis (FA) in humans. The aim of this study was to... -
Federal
TheG-308Avariant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution
U.S. Department of Health & Human Services —
Tumor Necrosis Factor-α (TNF-α) has been implicated in the pathogenesis of insulin resistance and obesity. The increased expression of TNF-α in adipose tissue has... -
Federal
Tumor necrosis factor-α and muscle wasting: a cellular perspective
U.S. Department of Health & Human Services —
Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential... -
Federal
Cell contact interactions in rheumatology, The Kennedy Institute for Rheumatology, London, UK, 1-2 June 2000
U.S. Department of Health & Human Services —
The intricate interactions that regulate relationships between endogenous tissue cells and infiltrating immune cells in the rheumatic joint, particularly in...
11 datasets found