18 datasets found
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Federal
The Tox21 10K Compound Library: Part 1 - Collaborative chemistry advancing toxicology
U.S. Environmental Protection Agency —
Table S1: Tox21 IDs mapped to NCGC IDs, PubChem IDs, and DSSTox IDs, and indicating NCATS, NTP and EPA partner library associations (date stamped February 24, 2020).... -
Federal
PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol
U.S. Department of Health & Human Services —
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been... -
Federal
PKQuest: volatile solutes – application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics
U.S. Department of Health & Human Services —
Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that... -
Federal
Evaluation of Existing QSAR Models and Structural Alerts and Development of New Ensemble Models for Genotoxicity Using a Newly Compiled Experimental Dataset
U.S. Environmental Protection Agency —
In this study, a major effort was undertaken to compile a large genotoxicity dataset (54,805 records for 9299 substances) from several public sources (e.g., TOXNET,... -
Federal
Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals
U.S. Environmental Protection Agency —
This is a new, open, and transparent database of toxicokinetic data supporting EPA decision making. The database has already become the basis of research efforts... -
Federal
PKQuest: capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics
U.S. Department of Health & Human Services —
Background It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This... -
Federal
Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data
U.S. Environmental Protection Agency —
Here are all of the data files used for this manuscript. Please note that this is all published data. Imran Shah 1.1060+ Chemicals and Chemical controls 2. Chemical... -
Federal
PFBS tissue concentrations and liver gene expression in mice
U.S. Environmental Protection Agency —
File contains raw data collected on body and organ weights of mice given PFBS and body burden of the chemical after intervals of several hours, as well as expression... -
Federal
Derivation of new Threshold of Toxicological Concern values for exposure via inhalation for environmentally-relevant chemicals
U.S. Environmental Protection Agency —
An effort was made to derive new inhalation TTC values using the EPA’s Toxicity Values database, ToxValDB. A total of 4703 substances captured in ToxValDB were... -
Federal
HTTK: R Package for High-Throughput Toxicokinetics
U.S. Environmental Protection Agency —
Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") as in Pearce et al. (2017) . Chemical-specific in vitro data have... -
Federal
The concentration of three anti-seizure medications in hair: the effects of hair color, controlling for dose and age
U.S. Department of Health & Human Services —
Background This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for... -
Federal
An evaluation of the performance of selected (Q)SARs/expert systems for predicting acute oral toxicity
U.S. Environmental Protection Agency —
Acute rat oral toxicity lethality data files, processed prediction files from 2 expert systems. This dataset is associated with the following publication: Nelms, M.,... -
Federal
Pharmacology of the critically ill
U.S. Department of Health & Human Services —
Pharmacology of the critically ill -
Federal
Generalised Read-Across Prediction using genra-py
U.S. Environmental Protection Agency —
Read-across (RAX) is a widely used data gap filling approach and the authors have developed a data-driven tool, called GenRA, to support expert-driven RAX. This work... -
Federal
Model Code Associated with "Challenges for extrapolation of risk from ingestion to inhalation exposure for per- and polyfluorinated alkyl acids and their precursors"
U.S. Environmental Protection Agency —
This ScienceHub entry contains a zip file with the pharmacokinetic modeling code used for the linked publication, "Challenges for extrapolation of risk from ingestion... -
Federal
Evaluating the Mouse Model for Estimation of Arsenic Bioavailability: Comparison of Estimates of Absolute Bioavailability of Inorganic Arsenic in Mouse, Humans, and Other Species
U.S. Environmental Protection Agency —
Mouse assays. This dataset is associated with the following publication: Diamond, G., K. Bradham, and D. Thomas. Evaluating the Mouse Model for Estimation of Arsenic... -
Federal
Absorption, distribution, metabolism, and elimination of seed-treatment pesticides following the dosing of Japanese quail (Coturnix japonica)
Department of the Interior —
Japanese quail (Coturnix japonica) were orally dosed with pesticide-treated or control-untreated wheat seeds. Pesticide treated wheat seeds were analytically verified... -
Federal
Anatoxin levels in mouse tissues after a single exposure and collected at various timepoints
U.S. Environmental Protection Agency —
Anatoxin levels in mouse tissues after a single exposure and collected at various timepoints
18 datasets found