14 datasets found
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Federal
Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts
U.S. Department of Health & Human Services —
Background Rapid, robust and reversible induction of transgene expression would significantly facilitate cancer gene therapy as well as allow the in vivo functional... -
Federal
Size does matter: overcoming the adeno-associated virus packaging limit
U.S. Department of Health & Human Services —
Recombinant adeno-associated virus (rAAV) vectors mediate long-term gene transfer without any known toxicity. The primary limitation of rAAV has been the small size... -
Federal
Highly efficient genetic transduction of primary human synoviocytes with concentrated retroviral supernatant
U.S. Department of Health & Human Services —
We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in... -
Federal
"Bronchial Artery Delivery of Viral Vectors for Gene delivery in Cystic Fibrosis; Superior to Airway Delivery?"
U.S. Department of Health & Human Services —
Background Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer... -
Federal
Gene therapy moves forward - The Second International Meeting on Gene and Cell Therapies of Arthritis and Related Disorders, 17-18 May 2001, Montpellier, France
U.S. Department of Health & Human Services —
The field of gene therapy for bone and joint disorders has grown considerably over the last two and a half years. Investigators have shown that ex vivo or in vivo... -
Federal
p53 in rheumatoid arthritis: friend or foe?
U.S. Department of Health & Human Services —
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, and apoptotic cell death in rheumatoid... -
Federal
Gene therapy in rheumatoid arthritis: how to target joint destruction?
U.S. Department of Health & Human Services —
Gene therapy in rheumatoid arthritis: how to target joint destruction? -
Federal
Approaches to enhancing the retroviral transduction of human synoviocytes
U.S. Department of Health & Human Services —
This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An... -
Federal
Gene therapy for lipid disorders
U.S. Department of Health & Human Services —
Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current... -
Federal
Research Article: BMC Medical Genetics
U.S. Department of Health & Human Services —
Background SFHR (small fragment homologous replacement)-mediated targeting is a process that has been used to correct specific mutations in mammalian cells. This... -
Federal
Beta-Adrenergic gene therapy for cardiovascular disease
U.S. Department of Health & Human Services —
Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for... -
Federal
Taking stock of gene therapy for cystic fibrosis
U.S. Department of Health & Human Services —
The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal... -
Federal
Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4
U.S. Department of Health & Human Services —
To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-... -
Federal
A bovine papillomavirus-1 based vector restores the function of the low-density lipoprotein receptor in the receptor-deficient CHO-ldlA7 cell line
U.S. Department of Health & Human Services —
Background The rationale of using bovine papillomavirus-1 (BPV-1) derived vectors in gene therapy protocols lies in their episomal maintenance at intermediate to high...
14 datasets found