25 datasets found
-
Federal
Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
U.S. Environmental Protection Agency —
Table of contents Table S1 DNT inventory List of sources and associated data collected for the development of the Bayesian hierarchical model. Table S2 Data... -
Federal
An ontology for developmental processes and toxicities of neural tube closure
U.S. Environmental Protection Agency —
The systems map described in this manuscript for neurulation will set the stage for constructing mathematical models and computer simulation of neural tube closure... -
Federal
PBPK_modeloutputs_readme
U.S. Environmental Protection Agency —
Contains values from pbpk models for each study on n-butanol effects. This dataset is associated with the following publication: Segal, D., A. Bale, L. Phillips, A.... -
Federal
Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity
U.S. Environmental Protection Agency —
This dataset consists of data from in vitro developmental neurotoxicity new approach methodologies (DNT-NAMs). Assays include evaluations of proliferation, apoptosis,... -
Federal
Moser_NTT_52:2015
U.S. Environmental Protection Agency —
data supporting manuscript figures. This dataset is associated with the following publication: Moser , V.C., P. Phillips , J. Hedge , and K. Mcdaniel.... -
Federal
Beasley_Impacts of a perinatal exposure to manganese coupled with maternal stress in rats: Maternal somatic measures and the postnatal growth and development of rat offspring_data_V1
U.S. Environmental Protection Agency —
Data set for the neurodevelopmental and somatic impacts of a perinatal exposure to stress coupled with Mn exposure on dams and their offspring. This dataset is... -
Federal
Raw Data for Jarema et al, 2022 Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish...
U.S. Environmental Protection Agency —
The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxics10050256/s1. Figure S1, Effect of DMSO on Light/Dark Locomotor... -
Federal
A comparative study of biostatistical pipelines for benchmark concentration modeling of in vitro screening assays
U.S. Environmental Protection Agency —
Supplementary data for "A comparative study of biostatistical pipelines for benchmark concentration modeling of in vitro screening assays". This dataset is associated... -
Federal
Iodine Deficiency Exacerbates Thyroidal and Neurological Effects of Developmental Perchlorate Exposure in the Neonatal and Adult Rat
U.S. Environmental Protection Agency —
Thyroid hormones status, brain molecular and structural changes, and neurobehavioral impairments following maternal exposure to perchlorate in a rodent pregnancy... -
Federal
Provides an overview of the analysis and associated files, scripts and datasets
U.S. Environmental Protection Agency —
This dataset contains the files, scripts and data that were used to run the simulations and data analyses for the manuscript. This dataset is associated with the... -
Federal
Methods for Thyroid Hormone Measurements in Neonatal Rat Brain
U.S. Environmental Protection Agency —
Serum and brain thyroid hormone measurements in rat brain. This dataset is associated with the following publication: Gilbert, M., J. Ford, C. Riutta, K.... -
Federal
Dataset for Chemical Signatures of neurodevelopmental disorders
U.S. Environmental Protection Agency —
This dataset contains the data, code and associated files for the manuscript Authored by Marable et al. This dataset is associated with the following publication:... -
Federal
Data for: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays
U.S. Environmental Protection Agency —
This dataset contains the raw data, Area under the curve measurements and EC50 values for effects of 146 compounds (136 unique plus 10 biological replicates) on... -
Federal
Neurite outgrowth in human iPSC-derived neurons
U.S. Environmental Protection Agency —
Data on morphology of rat and human neurons in cell culture. This dataset is associated with the following publication: Druwe, I., T. Freudenrich , K. Wallace , T.... -
Federal
Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents
U.S. Environmental Protection Agency —
Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the... -
Federal
Gestational Exposure to Perchlorate in the rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain
U.S. Environmental Protection Agency —
This dataset contains results from rodent study. Thyroid hormones and brain endpoints are reported for pregnant rat dams and progeny on gestational day 20 following... -
Federal
Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity
U.S. Environmental Protection Agency —
R-language data files from "Carstens KE, Freudenrich T, Wallace K, Choo S, Carpenter A, Smeltz M, Clifton MS, Henderson WM, Richard AM, Patlewicz G, Wetmore BA, Paul... -
Federal
This file contains data used to generate figures shown in Phelps et al. Microbial colonization is required for normal neurobehavioral development in zebrafish. Scientific Reports. 2017.
U.S. Environmental Protection Agency —
Data used to generate figures shown in Phelps et al. This dataset is associated with the following publication: Phelps, D., N. Brinkman, S. Keely, E. Anneken, T.... -
Federal
MEA 86 Compound data
U.S. Environmental Protection Agency —
This data file contains the full raw parameter data for the 86 compounds tested in the developmental MEA assay, as well as Area Under the Curve (AUC) calculations and... -
Federal
Doc Title: Adult Hippocampal Neurogenesis is Impaired by Transient Developmental Thyroid Hormone Disruption
U.S. Environmental Protection Agency —
Severe thyroid hormone (TH) deprivation during development impairs neurogenesis throughout the brain. The hippocampus also maintains a capacity for neurogenesis...
25 datasets found