The systems map described in this manuscript for neurulation will set the stage for constructing mathematical models and computer simulation of neural tube closure for human-relevant AOPs and predictive toxicology of neural tube defects such as spina bifida. This dataset is not publicly accessible because: The data for the systems map has been obtained from comprehensive literature review. It can be accessed through the following means: Contact the corresponding author Harm J. Heusinkveld, Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720BA, Bilthoven, The Netherlands. Email: harm.heusinkveld@rivm.nl. Format: Not availabie.
This dataset is associated with the following publication:
Heusinkveld, H., Y. Staal, N. Baker, G. Daston, T. Knudsen, and A. Piersma. An ontology for developmental processes and toxicities of neural tube closure. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 99: 160-167, (2021).