An ontology for developmental processes and toxicities of neural tube closure

The systems map described in this manuscript for neurulation will set the stage for constructing mathematical models and computer simulation of neural tube closure for human-relevant AOPs and predictive toxicology of neural tube defects such as spina bifida. This dataset is not publicly accessible because: The data for the systems map has been obtained from comprehensive literature review. It can be accessed through the following means: Contact the corresponding author Harm J. Heusinkveld, Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720BA, Bilthoven, The Netherlands. Email: harm.heusinkveld@rivm.nl. Format: Not availabie. This dataset is associated with the following publication: Heusinkveld, H., Y. Staal, N. Baker, G. Daston, T. Knudsen, and A. Piersma. An ontology for developmental processes and toxicities of neural tube closure. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 99: 160-167, (2021).

[
  "020:00"
]

{
  "fn": "Thomas Knudsen",
  "hasEmail": "mailto:knudsen.thomas@epa.gov"
}

[]

[
  "Predictive Toxicology",
  "developmental neurotoxicity",
  "neural tube defects",
  "retinoic acid",
  "systems biology",
  "virtual embryo"
]

[
  "020:095"
]

{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}

[
  "https://doi.org/10.1016/j.reprotox.2020.09.002"
]

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