27 datasets found
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Federal
ClinicalTrials.gov
U.S. Department of Health & Human Services —
Provides patients, family members, health care professionals, and members of the public easy access to information on clinical trials for a wide range of diseases and... -
Federal
National Database for Clinical Trials Related to Mental Illness (NDCT)
U.S. Department of Health & Human Services —
The National Database for Clinical Trials Related to Mental Illness (NDCT) is an extensible informatics platform for relevant data at all levels of biological and... -
Federal
Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports
U.S. Department of Health & Human Services —
Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. Methods... -
Federal
Problems in dealing with missing data and informative censoring in clinical trials
U.S. Department of Health & Human Services —
A common problem in clinical trials is the missing data that occurs when patients do not complete the study and drop out without further measurements. Missing data... -
Federal
On the probability of cost-effectiveness using data from randomized clinical trials
U.S. Department of Health & Human Services —
Background Acceptability curves have been proposed for quantifying the probability that a treatment under investigation in a clinical trial is cost-effective. Various... -
Federal
New immunosuppressive drugs in heart transplantation
U.S. Department of Health & Human Services —
Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants... -
Federal
Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies
U.S. Department of Health & Human Services —
Background We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time... -
Federal
The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study
U.S. Department of Health & Human Services —
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this... -
Federal
Treating patients with low high-density lipoprotein cholesterol: choices, issues and opportunities
U.S. Department of Health & Human Services —
Three clinical trials have recently focused on the benefits of lipid-regulating therapy in populations with normocholesterolaemia and low high-density lipoprotein... -
Federal
Implications of recent hypertension trials for the generalist physician: whom do we treat, and how?
U.S. Department of Health & Human Services —
The publication of the results of the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) and the termination of the doxazocin arm of the Antihypertensive and... -
Federal
Clinical trials in developing countries: Discussions at the '9th International Symposium on Long Term Clinical Trials', London, UK, 19-20 June 2000
U.S. Department of Health & Human Services —
This symposium provided a useful forum for the discussion of issues relating to the design and conduct of clinical trials. There is a need for greater awareness of... -
Federal
ELITE II and Val-HeFT are different trials: together what do they tell us?
U.S. Department of Health & Human Services —
The Losartan Heart Failure Survival Study (ELITE II) and the Valsartan Heart Failure Trial (Val-HeFT) both evaluated the efficacy and tolerability of a selective... -
Federal
Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trials
U.S. Department of Health & Human Services —
Background We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic... -
Federal
Systematic reviews of complementary therapies – an annotated bibliography. Part 3: Homeopathy
U.S. Department of Health & Human Services —
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical... -
Federal
Biventricular pacing in heart failure: update on results from clinical trials
U.S. Department of Health & Human Services —
Biventricular pacing or resynchronisation therapy is a non-pharmacological therapy for patients with chronic heart failure. Since being originally described in 1994,... -
Federal
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!
U.S. Department of Health & Human Services —
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power,... -
Federal
Hypothesis to explain poor outcomes in the ALLHAT and V-HeFT trials: decreased expression of heat shock proteins
U.S. Department of Health & Human Services —
An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial... -
Federal
Publication bias in gastroenterological research – a retrospective cohort study based on abstracts submitted to a scientific meeting
U.S. Department of Health & Human Services —
Background The aim of this study was to examine the determinants of publication and whether publication bias occurred in gastroenterological research. Methods A... -
Federal
Diuretics: again the first step in the treatment of most patients with hypertension
U.S. Department of Health & Human Services —
The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to... -
Federal
Fundamental deficiencies in the megatrial methodology
U.S. Department of Health & Human Services —
The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects....
27 datasets found