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Diuretics: again the first step in the treatment of most patients with hypertension

Published by National Institutes of Health | U.S. Department of Health & Human Services | Catalog Last Checked: July 31, 2026 at 09:58 PM | Dataset Last Updated: September 06, 2025
The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to begin treatment for hypertension. Every comparison of diuretics with other drugs has shown that the benefits of diuretics are equivalent to, or better than, other options. These findings, together with other practical reasons, such as left ventricular mass reducing effect, easy administration, few side effects and low cost, suggest that diuretics should regain their primacy as the first step in drug management of hypertension.

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