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Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. ...
Search relevance: 1.00 | Views last month: 17 | Catalog Last Checked: September 10, 2026 at 07:48 PM -
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this paper, I compare four...
Search relevance: 1.00 | Views last month: 10 | Catalog Last Checked: September 10, 2026 at 08:17 PM -
A common problem in clinical trials is the missing data that occurs when patients do not complete the study and drop out without further measurements. Missing data cause the usual statistical...
Search relevance: 1.00 | Views last month: 7 | Catalog Last Checked: September 10, 2026 at 08:26 PM -
Three clinical trials have recently focused on the benefits of lipid-regulating therapy in populations with normocholesterolaemia and low high-density lipoprotein (HDL)-cholesterol. Two secondary...
Search relevance: 1.00 | Views last month: 6 | Catalog Last Checked: September 10, 2026 at 08:20 PM -
Systematic reviews of complementary therapies – an annotated bibliography. Part 2: Herbal medicine
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major...
Search relevance: 1.00 | Views last month: 6 | Catalog Last Checked: September 10, 2026 at 07:41 PM -
The publication of the results of the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) and the termination of the doxazocin arm of the Antihypertensive and Lipid Lowering Treatment to...
Search relevance: 1.00 | Views last month: 5 | Catalog Last Checked: September 10, 2026 at 07:50 PM -
Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year....
Search relevance: 1.00 | Views last month: 5 | Catalog Last Checked: September 10, 2026 at 08:31 PM -
Background Readers may question the interpretation of findings in clinical trials when multiple outcome measures are used without adjustment of the p-value. This question arises because...
Search relevance: 1.00 | Views last month: 4 | Catalog Last Checked: September 10, 2026 at 08:28 PM -
Background We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic databases. However, complete...
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: September 10, 2026 at 07:36 PM -
An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) with doxazosin and...
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: September 10, 2026 at 08:24 PM -
Background We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time parameters (such as...
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: September 10, 2026 at 07:51 PM -
The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to begin treatment for...
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: September 10, 2026 at 08:28 PM -
Background Acceptability curves have been proposed for quantifying the probability that a treatment under investigation in a clinical trial is cost-effective. Various definitions and...
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: September 10, 2026 at 08:19 PM -
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the...
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: September 10, 2026 at 08:33 PM -
The Losartan Heart Failure Survival Study (ELITE II) and the Valsartan Heart Failure Trial (Val-HeFT) both evaluated the efficacy and tolerability of a selective angiotensin II receptor antagonist...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 08:26 PM -
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients differ widely from one another in...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 07:46 PM -
Research Article: Current Controlled Trials in Cardiovascular Medicine
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 08:17 PM -
In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 07:55 PM -
Biventricular pacing or resynchronisation therapy is a non-pharmacological therapy for patients with chronic heart failure. Since being originally described in 1994, biventricular pacing has...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 08:15 PM -
The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 10, 2026 at 08:29 PM
