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Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year....
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: September 07, 2025 at 11:02 PM -
The publication of the results of the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) and the termination of the doxazocin arm of the Antihypertensive and Lipid Lowering Treatment to...
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: September 07, 2025 at 10:59 AM -
Background We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic databases. However, complete...
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: September 07, 2025 at 07:42 AM -
In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with...
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The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to begin treatment for...
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Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: September 07, 2025 at 11:57 PM -
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients differ widely from one another in...
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Three clinical trials have recently focused on the benefits of lipid-regulating therapy in populations with normocholesterolaemia and low high-density lipoprotein (HDL)-cholesterol. Two secondary...
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Biventricular pacing or resynchronisation therapy is a non-pharmacological therapy for patients with chronic heart failure. Since being originally described in 1994, biventricular pacing has...
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Background We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time parameters (such as...
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Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. ...
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Background The aim of this study was to examine the determinants of publication and whether publication bias occurred in gastroenterological research. ...
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The Losartan Heart Failure Survival Study (ELITE II) and the Valsartan Heart Failure Trial (Val-HeFT) both evaluated the efficacy and tolerability of a selective angiotensin II receptor antagonist...
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Are there fundamental deficiencies in the megatrial methodology?
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Background Acceptability curves have been proposed for quantifying the probability that a treatment under investigation in a clinical trial is cost-effective. Various definitions and...
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The recent scientific session of the American College of Cardiology (ACC), held in Orlando, provided a forum for ongoing cardiovascular clinical trials from around the world. The high point was...
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An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) with doxazosin and...
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Research Article: Current Controlled Trials in Cardiovascular Medicine
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Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this paper, I compare four...
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The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: September 07, 2025 at 10:23 PM
