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Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. ...
Search relevance: 1.00 | Views last month: 13 | Catalog Last Checked: July 31, 2026 at 09:14 PM -
The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to begin treatment for...
Search relevance: 1.00 | Views last month: 12 | Catalog Last Checked: July 31, 2026 at 09:58 PM -
A common problem in clinical trials is the missing data that occurs when patients do not complete the study and drop out without further measurements. Missing data cause the usual statistical...
Search relevance: 1.00 | Views last month: 6 | Catalog Last Checked: July 31, 2026 at 09:55 PM -
The publication of the results of the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) and the termination of the doxazocin arm of the Antihypertensive and Lipid Lowering Treatment to...
Search relevance: 1.00 | Views last month: 5 | Catalog Last Checked: July 31, 2026 at 09:17 PM -
Background Acceptability curves have been proposed for quantifying the probability that a treatment under investigation in a clinical trial is cost-effective. Various definitions and...
Search relevance: 1.00 | Views last month: 4 | Catalog Last Checked: July 31, 2026 at 09:48 PM -
Background Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this paper, I compare four...
Search relevance: 1.00 | Views last month: 4 | Catalog Last Checked: July 31, 2026 at 09:46 PM -
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the...
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: July 31, 2026 at 10:04 PM -
Background We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time parameters (such as...
Search relevance: 1.00 | Views last month: 3 | Catalog Last Checked: July 31, 2026 at 09:18 PM -
Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year....
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: July 31, 2026 at 10:01 PM -
Background We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic databases. However, complete...
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: July 31, 2026 at 09:02 PM -
Three clinical trials have recently focused on the benefits of lipid-regulating therapy in populations with normocholesterolaemia and low high-density lipoprotein (HDL)-cholesterol. Two secondary...
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: July 31, 2026 at 09:49 PM -
In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with...
Search relevance: 1.00 | Views last month: 2 | Catalog Last Checked: July 31, 2026 at 09:22 PM -
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients differ widely from one another in...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: July 31, 2026 at 09:12 PM -
An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) with doxazosin and...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: July 31, 2026 at 09:53 PM -
Biventricular pacing or resynchronisation therapy is a non-pharmacological therapy for patients with chronic heart failure. Since being originally described in 1994, biventricular pacing has...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: July 31, 2026 at 09:43 PM -
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major...
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Background The aim of this study was to examine the determinants of publication and whether publication bias occurred in gastroenterological research. ...
Search relevance: 1.00 | Views last month: 1 | Catalog Last Checked: July 31, 2026 at 09:45 PM -
The Losartan Heart Failure Survival Study (ELITE II) and the Valsartan Heart Failure Trial (Val-HeFT) both evaluated the efficacy and tolerability of a selective angiotensin II receptor antagonist...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: July 31, 2026 at 09:56 PM -
Are there fundamental deficiencies in the megatrial methodology?
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: July 31, 2026 at 09:15 PM -
The recent scientific session of the American College of Cardiology (ACC), held in Orlando, provided a forum for ongoing cardiovascular clinical trials from around the world. The high point was...
Search relevance: 1.00 | Views last month: 0 | Catalog Last Checked: July 31, 2026 at 10:02 PM
