19 datasets found
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Federal
Watford_Novel_application__NPMI_Biomedlit_genesets_usecase_breast_cancer
U.S. Environmental Protection Agency —
We present a novel use of normalized pointwise mutual information (NPMI) to mine biomedical literature for gene associations with biological concepts as represented... -
Federal
OPERA models for predicting physicochemical properties and environmental fate endpoints
U.S. Environmental Protection Agency —
For the purpose of this modeling study, extensive curation work was conducted on 13 publicly available PHYSPROP physicochemical property and environmental fate... -
Federal
Predictive Models for In Vitro Toxicokinetic Parameters to Inform High-throughput Risk-assessment_Prachi
U.S. Environmental Protection Agency —
The data used in this analysis was obtained from published literature and available through the high-throughput toxicokinetic (HTTK) R package. The dataset consists... -
Federal
Revisiting Five Years of CASMI Contests with EPA Identification Tool
U.S. Environmental Protection Agency —
An investigation was performed on each of the individual CASMI datasets to identify whether the chemicals were present in DSSTox, the database underlying the... -
Federal
KPF_Examining the Utility of In Vitro Bioactivity as a Protective Point of Departure: A Case Study_APCRA
U.S. Environmental Protection Agency —
The files and .R scripts here are provided to aid in understanding and reproduction of the analyses in the submitted paper, "Examining the Utility of In Vitro... -
Federal
RJudson_Mansouri_CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity
U.S. Environmental Protection Agency —
Data and supplemental files from COMPARA (A large-scale modeling project). COMPARA combined multiple models developed in collaboration with modelers and computational... -
Federal
Development, validation and integration of in silico models to identify androgen active chemicals
U.S. Environmental Protection Agency —
A diverse data set of 1667 chemicals with AR experimental activity were provided by the U.S. EPA from the oxicity Forecaster (ToxCast) program which generates data... -
Federal
Predicting_Systemic_Toxicity_Effects_ArchTox_2017_Data
U.S. Environmental Protection Agency —
In an effort to address a major challenge in chemical safety assessment, alternative approaches for characterizing systemic effect levels, a predictive model was... -
Federal
Minimal_Set_of_In_Vitro_ER_Agonist_Assays_Selection_RegToxPharm_Data
U.S. Environmental Protection Agency —
A dataset for the manuscript which demonstrates that it is possible to achieve levels of performance equivalent to the full 16 assay ER agonist model against both in... -
Federal
ToxRefDB version 2.0: Improved utility for predictive and retrospective toxicology analyses
U.S. Environmental Protection Agency —
ToxRefDB comprises information from over fifty years of in vivo toxicity data. The database includes information for over 1000 chemicals, and is being used as a... -
Federal
Judson_Mansouri_Automated_Chemical_Curation_QSAREnvRes_Data
U.S. Environmental Protection Agency —
Here we describe the development of an automated KNIME workflow to curate and correct errors in the structure and identity of chemicals using the publically available... -
Federal
Judson_Kleinstreuer_Development and Validation of a Computational Model for Androgen Receptor Activity.
U.S. Environmental Protection Agency —
Data on 1855 chemicals were generated during ToxCast Phases I and II and Tox21 screening using 11 AR-related in vitro assays to build a computational network model... -
Federal
Retrospective_Mining_of_Tox_Data_Anemia_Case_Study_RegToxPharm Data
U.S. Environmental Protection Agency —
Data from a study to critically examine some of the issues of using data from ToxRefDB, a database largely composed of guideline studies for pesticidal active... -
Federal
Predicting Estrogenicity of a Group of Substituted Phenols_IATA
U.S. Environmental Protection Agency —
Data are summarized in a two-dimensional data matrix that was developed for each substance for hazard characterization (Tables S1–S3). In the horizontal direction of... -
Federal
Interactive Chemical Safety for Sustainablity Toxicity Forecaster Dashboard
U.S. Environmental Protection Agency —
EPA researchers have been using advances in computational toxicology to address lack of data on the thousands of chemicals. EPA released chemical data on 1,800... -
Federal
Read_Across_Prediction_of_Estrogenicity_for_Hindered_Phenols_2017_Data
U.S. Environmental Protection Agency —
Read-across is an important data gap filling technique used within category and analog approaches for regulatory hazard identification and risk assessment. Although... -
Federal
2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation
U.S. Environmental Protection Agency —
The objectives of this work were to: 1) develop an integrated analysis of chemical-mediated effects on steroidogenesis in the HT-H295R assay; and, 2) evaluate whether... -
Federal
Watt_HTS_Uncertainty_Quantification_2017_data
U.S. Environmental Protection Agency —
In this work, we introduce a new method for uncertainty quantification in ToxCast data. We explore how unavoidable uncertainties in the data result in uncertainties... -
Federal
"MS-Ready” structures for non-targeted high-resolution mass spectrometry screening studies
U.S. Environmental Protection Agency —
The dataset(s) supporting the conclusions of this article are available via the CompTox Chemistry Dashboard Downloads Page...
19 datasets found