5 datasets found
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Federal
Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data
U.S. Environmental Protection Agency —
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were... -
Federal
Dataset and code for cross species applicability of an AOP network for thyroid hormone system disruption
U.S. Environmental Protection Agency —
The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database... -
Federal
Extracting and benchmarking emerging adverse outcome pathway knowledge
U.S. Environmental Protection Agency —
A collection of R scripts useful for extracting and analyzing adverse outcome pathway network data from the adverse outcome pathway wiki (aopwiki.org). This dataset... -
Federal
Differentiating Pathway-Specific From Nonspecific Effects in High-Throughput Toxicity Data: A Foundation for Prioritizing Adverse Outcome Pathway Development
U.S. Environmental Protection Agency —
Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations... -
Federal
Adverse Outcome Pathway Networks II: Network Analytics
U.S. Environmental Protection Agency —
The data set provides a set of txt files and cytoscape files that were used to construct the example AOP networks included in the paper. Additionally, a supplementary...
5 datasets found