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Federal
Diagnostic and treatment characteristics of polycystic ovary syndrome: descriptive measurements of patient perception and awareness from 657 confidential self-reports
U.S. Department of Health & Human Services —
Background This investigation was undertaken to describe patient perception and awareness of the polycystic ovary syndrome (PCOS), the most common cause of... -
Federal
An MCASE approach to the search of a cure for Parkinson's Disease.
U.S. Department of Health & Human Services —
Background Parkinson's disease is caused by a dopamine deficiency state in the fore brain area. Dopamine receptor agonists, MAO-B inhibitors, and N-Methyl-D-Aspartate... -
Federal
Analysis of a human brain transcriptome map
U.S. Department of Health & Human Services —
Background Genome wide transcriptome maps can provide tools to identify candidate genes that are over-expressed or silenced in certain disease tissue and increase our... -
Federal
B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus
U.S. Department of Health & Human Services —
B cells and B-cell/T-cell collaborations are instrumental in the pathophysiology of systemic lupus erythematosus (SLE). This commentary highlights in particular the... -
Federal
Alterations of E-cadherin and β-catenin in gastric cancer
U.S. Department of Health & Human Services —
Background The E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the... -
Federal
Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions
U.S. Department of Health & Human Services —
Background The aim of this study was to determine and compare patients' and physicians' perceptions of benefits and risks of long term benzodiazepine use for insomnia... -
Federal
The diagnostic value of liver biopsy
U.S. Department of Health & Human Services —
Background Since the introduction of molecular diagnostic tools such as markers for hepatitis C and different autoimmune diseases, liver biopsy is thought to be... -
Federal
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
U.S. Department of Health & Human Services —
Background Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket.... -
Federal
Genetic polymorphisms in lung disease: bandwagon or breakthrough?
U.S. Department of Health & Human Services —
The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to... -
Federal
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
U.S. Department of Health & Human Services —
Great advances have been made in describing the intracellular pathways and genes that are activated by bacterial products. New definitions and therapies for sepsis... -
Federal
Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study
U.S. Department of Health & Human Services —
Background Celiac disease has a strong genetic association with HLA. However, this association only explains approximately half of the sibling risk for celiac... -
Federal
Impact of false-positive mammography on subsequent screening attendance and risk of cancer
U.S. Department of Health & Human Services —
Background One area of concern within the largely successful UK National Health Service breast screening programme is the relatively high proportion of women showing... -
Federal
Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart
U.S. Department of Health & Human Services —
Background Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported... -
Federal
Staphylococcal peptidoglycans induce arthritis
U.S. Department of Health & Human Services —
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN),... -
Federal
UAG readthrough in mammalian cells: Effect of upstream and downstream stop codon contexts reveal different signals
U.S. Department of Health & Human Services —
Background Translation termination is mediated through an interaction between the release factors eRF1 and eRF3 and the stop codon within its nucleotide context.... -
Federal
Statistical issues in randomized trials of cancer screening
U.S. Department of Health & Human Services —
Background The evaluation of randomized trials for cancer screening involves special statistical considerations not found in therapeutic trials. Although some of... -
Federal
13th Annual Congress of the European Society of Intensive Care Medicine, Rome, Italy, 1-4 October 2000
U.S. Department of Health & Human Services —
13th Annual Congress of the European Society of Intensive Care Medicine, Rome, Italy, 1-4 October 2000 -
Federal
Oral cancer treatment costs in Greece and the effect of advanced disease
U.S. Department of Health & Human Services —
Background The main purpose of the study was to quantify the direct costs of oral cancer treatment to the healthcare system of Greece. Another aim was to identify... -
Federal
Prospectively validated predictions of shock and organ failure in individual septic surgical patients: the Systemic Mediator Associated Response Test
U.S. Department of Health & Human Services —
Introduction: Clinically useful predictions of end-organ function and failure in severe sepsis may be possible through analyzing the interactions among demographics,... -
Federal
The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals
U.S. Department of Health & Human Services —
Background The human NOTCH4 gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiological roles. In a British linkage study, NOTCH4...