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Federal
A surrogate-based approach for post-genomic partner identification
U.S. Department of Health & Human Services —
Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present... -
Federal
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder
U.S. Department of Health & Human Services —
Background Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-... -
Federal
Influence of twenty-five per cent human serum albumin on total and ionized calcium concentrations
U.S. Department of Health & Human Services —
Background: A inverse correlation has been found between changes in ionized calcium concentrations and the addition of albumin in vitro, which may explain adverse... -
Federal
Abnormal expression of p27kip1 protein in levator ani muscle of aging women with pelvic floor disorders – a relationship to the cellular differentiation and degeneration
U.S. Department of Health & Human Services —
Background Pelvic floor disorders affect almost 50% of aging women. An important role in the pelvic floor support belongs to the levator ani muscle. The p27/kip1... -
Federal
Prescribing patterns in premenstrual syndrome
U.S. Department of Health & Human Services —
Background Over 300 therapies have been proposed for premenstrual syndrome. To date there has been only one survey conducted in the UK of PMS treatments prescribed by... -
Federal
The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
U.S. Department of Health & Human Services —
Objective To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically... -
Federal
Alarms in the intensive care unit: how can the number of false alarms be reduced?
U.S. Department of Health & Human Services —
Many alarms, as they now exist in most monitoring systems, are not usually perceived as helpful by the medical staff because of the high incidence of false alarms.... -
Federal
Treatment of established postoperative nausea and vomiting: a quantitative systematic review
U.S. Department of Health & Human Services —
Background The relative efficacy of antiemetics for the treatment of postoperative nausea and vomiting (PONV) is poorly understood. Methods Systematic search... -
Federal
Evaluation of thresholds for the detection of binding sites for regulatory proteins in
U.S. Department of Health & Human Services —
Background Sites in DNA that bind regulatory proteins can be detected computationally in various ways. Pattern discovery methods analyze collections of genes... -
Federal
The methionine salvage pathway in
U.S. Department of Health & Human Services —
Background Polyamine synthesis produces methylthioadenosine, which has to be disposed of. The cell recycles it into methionine through methylthioribose (MTR). Very... -
Federal
B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection
U.S. Department of Health & Human Services —
The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar to... -
Federal
Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses
U.S. Department of Health & Human Services —
Background This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the... -
Federal
Do we need clinical trials to test the ability of transdermal HRT to prevent coronary heart disease?
U.S. Department of Health & Human Services —
Postmenopausal hormone replacement therapy (HRT) with oral oestrogen was predicted to reduce coronary heart disease (CHD) risk by 50%. Randomized controlled trials... -
Federal
Effects of herbivory on the reproductive effort of 4 prairie perennials
U.S. Department of Health & Human Services —
Background Herbivory can affect every aspect of a plant's life. Damaged individuals may show decreased survivorship and reproductive output. Additionally, specific... -
Federal
Normalization and analysis of DNA microarray data by self-consistency and local regression
U.S. Department of Health & Human Services —
A robust semi-parametric normalization technique has been developed, based on the assumption that the large majority of genes will not have their relative expression... -
Federal
Practice and professional development plans (PPDPs): results of a feasibility study
U.S. Department of Health & Human Services —
Background Dissatisfaction with uniprofessional education structures as a means of improving the quality of healthcare has led to proposals to develop ways of... -
Federal
HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8
U.S. Department of Health & Human Services —
Background T cells from HIV+ and aged individuals show parallels in terms of suppressed proliferative activity and interleukin-2 (I1-2) production and an increased... -
Federal
Pro/con clinical debate: The use of a protected specimen brush in the diagnosis of ventilator associated pneumonia
U.S. Department of Health & Human Services —
Although mechanical ventilation is instituted as a life-saving technique, it may lead to complications that can negatively impact on patients' morbidity and/or... -
Federal
Four signature motifs define the first class of structurally related large coiled-coil proteins in plants.
U.S. Department of Health & Human Services —
Background Animal and yeast proteins containing long coiled-coil domains are involved in attaching other proteins to the large, solid-state components of the cell.... -
Federal
Human papilloma viruses and cervical tumours: mapping of integration sites and analysis of adjacent cellular sequences
U.S. Department of Health & Human Services —
Background In cervical tumours the integration of human papilloma viruses (HPV) transcripts often results in the generation of transcripts that consist of hybrids of...