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Federal
Alterations of E-cadherin and β-catenin in gastric cancer
U.S. Department of Health & Human Services —
Background The E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the... -
Federal
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
U.S. Department of Health & Human Services —
Great advances have been made in describing the intracellular pathways and genes that are activated by bacterial products. New definitions and therapies for sepsis... -
Federal
Continuous haemofiltration in the intensive care unit
U.S. Department of Health & Human Services —
Continuous renal replacement therapy (CRRT) was first described in 1977 for the treatment of diuretic-unresponsive fluid overload in the intensive care unit (ICU).... -
Federal
Weather conditions and sudden sensorineural hearing loss
U.S. Department of Health & Human Services —
Background Climatic or meteorological condition changes have been implicated in the pathogenesis of Idiopathic Sudden Sensorineural Hearing Loss (ISSHL). We... -
Federal
Use of intravenous antiarrhythmics to identify concealed Brugada syndrome
U.S. Department of Health & Human Services —
Cardiology has recently witnessed the production of an overwhelming amount of data through the advances made in genetics and molecular biology research. Understanding... -
Federal
Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions
U.S. Department of Health & Human Services —
Background The aim of this study was to determine and compare patients' and physicians' perceptions of benefits and risks of long term benzodiazepine use for insomnia... -
Federal
Genetic polymorphisms in lung disease: bandwagon or breakthrough?
U.S. Department of Health & Human Services —
The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to... -
Federal
Modeling of failure mode in knee ligaments depending on the strain rate
U.S. Department of Health & Human Services —
Background The failure mechanism of the knee ligament (bone-ligament-bone complex) at different strain rates is an important subject in the biomechanics of the knee.... -
Federal
Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry
U.S. Department of Health & Human Services —
Background Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then... -
Federal
Is endosonography an effective method for detection and local staging of the ampullary carcinoma? A prospective study
U.S. Department of Health & Human Services —
Background The relatively rare carcinoma of the ampulla of Vater is a neoplasia with a good prognosis compared to pancreatic cancer. Preoperative staging is important... -
Federal
Quantitative analysis of DNA levels in maternal plasma in normal and Down syndrome pregnancies
U.S. Department of Health & Human Services —
Background We investigated fetal and total DNA levels in maternal plasma in patients bearing fetuses affected with Down syndrome in comparison to controls carrying... -
Federal
Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol
U.S. Department of Health & Human Services —
Background Evidence from recent literature shows that protocol-directed extubation is a useful approach to liberate patients from mechanical ventilation (MV).... -
Federal
Genetic determinants of mammographic density
U.S. Department of Health & Human Services —
Background Changes in breast density are highly correlated with steroid hormone exposure. Materials and methods In a cross-sectional study of 396 Caucasian and... -
Federal
To keep the catch – that is the question: a personal account of the 3rd Annual EULAR Congress, Stockholm
U.S. Department of Health & Human Services —
The 3rd Annual EULAR Congress, held in Stockholm on 12–15 June 2002, had a turnout of 8300 delegates, almost identical to last year's record attendance level in... -
Federal
Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug
U.S. Department of Health & Human Services —
Background Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an... -
Federal
Auto-protective redox buffering systems in stimulated macrophages
U.S. Department of Health & Human Services —
Background Macrophages, upon encounter with micro-organisms or stimulated by cytokines, produce various effector molecules aimed at destroying the foreign agents and... -
Federal
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)
U.S. Department of Health & Human Services —
Background Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of... -
Federal
Staphylococcal peptidoglycans induce arthritis
U.S. Department of Health & Human Services —
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN),... -
Federal
Cell fate decision: T-helper 1 and 2 subsets in immune responses
U.S. Department of Health & Human Services —
After activation CD4+ helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine... -
Federal
Atrial fibrillation in a primary care practice: prevalence and management
U.S. Department of Health & Human Services —
Background Atrial fibrillation is a common serious cardiac arrhythmia. Knowing the prevalence of atrial fibrillation and documentation of medical management are...