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Federal
High-throughput Toxicogenomic Screening of Chemicals in the Environment Using Metabolically Competent, Human-derived Hepatic Cell Cultures
U.S. Environmental Protection Agency —
Gene expression data from the Fluidigm qRT-PCR arrays was analyzed in R (v3.6.1; R Foundation for Statistical Computing, 2019). Prior to processing through the tcpl... -
Federal
Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library
U.S. Environmental Protection Agency —
The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist... -
Federal
Predict_Organ_Toxicity_ChemResTox_Data
U.S. Environmental Protection Agency —
We use a supervised machine learning strategy to systematically investigate the relative importance of study type, machine learning algorithm, and type of descriptor... -
Federal
Watt_HTS_Uncertainty_Quantification_2017_data
U.S. Environmental Protection Agency —
In this work, we introduce a new method for uncertainty quantification in ToxCast data. We explore how unavoidable uncertainties in the data result in uncertainties... -
Federal
High-Throughput Transcriptomics Platform for Screening Environmental Chemicals
U.S. Environmental Protection Agency —
We screened 44 chemicals in MCF7 cells in concentration response and generated HTTr data using the TempO-Seq hWTv1 assay. First, we provide an outline of the quality... -
Federal
Dataset for journal article 'The DevTox Germ Layer Reporter Platform: An Assay Adaptation of the Human Pluripotent Stem Cell Test'
U.S. Environmental Protection Agency —
The zip file enclosed contains README_Gamble_DevTox GLR_Sup Data_v1.docx, Gamble_DevTox GLR_Sup Fig_Submission_v1.docx, Gamble_DevTox GLR_Tables_Submission_v1.xlsx,... -
Federal
Simmons_DeGroot_Metabolism_mRNA_transfection_ApplInVitroTox_Data
U.S. Environmental Protection Agency —
The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS)... -
Federal
Judson_RefChem_InVitro_Assays
U.S. Environmental Protection Agency —
This supplemental material describes two sets of methods; first, it briefly describes the process used to create the EPA’s LitDB database, and second, it describes... -
Federal
Dataset for ORD-033294: Mining a human transcriptome database for chemical modulators of NRF2
U.S. Environmental Protection Agency —
Gene Expression Omnibus and ArrayExpress archived study numbers of microarray data used in the study. This dataset is associated with the following publication:... -
Federal
A cross-platform approach to characterize and screen potential neurovascular unit toxicants
U.S. Environmental Protection Agency —
Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and... -
Federal
Prioritization of chemicals for effects on steroidogenesis using an integrated statistical approach to high-throughput H295R data
U.S. Environmental Protection Agency —
HT-H295R data was downloaded using the ToxCast pipeline (tcpl) R package and is publicly available. Multi-concentration level 0 data from invitrodb (version 3.1) were... -
Federal
High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
U.S. Environmental Protection Agency —
Repository for supplemental files and code for paper titled "High-throughput AR Dimerization Assay Identifies Androgen Disrupting Chemicals and Metabolites", 2022.... -
Federal
Targeted Per- and Polyfluoroalkyl Substances (PFAS) Assessments for High Throughput Screening: Analytical and Testing Considerations to Inform a PFAS Stock Quality Evaluation Framework
U.S. Environmental Protection Agency —
Data for "Smeltz MG, Clifton MS, Henderson WM, McMillan L, Wetmore BA. Targeted Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening:... -
Federal
Evaluation of a Multiplexed, Multispecies Nuclear Receptor Assay for Chemical Hazard Assessment
U.S. Environmental Protection Agency —
Table S1. All chemicals and AC50 from invitrodb v3 for human FACTORIAL-TRANS assay endpoints. Table S2. Agreement with OECD reference AR agonists. Table S3. Agreement... -
Federal
Chemical Screening in an Estrogen Receptor Transactivation Assay with Metabolic Competence
U.S. Environmental Protection Agency —
This is an original dataset generated at the U.S. EPA. Data was analyzed with the ToxCast Pipeline and deposited for release in invitroDB accessible via the U.S. EPA... -
Federal
Evaluation of a high-throughput H295R homogenous time resolved fluorescence assay for androgen and estrogen steroidogenesis screening
U.S. Environmental Protection Agency —
Dataset for 'Evaluation of a high-throughput H295R homogenous time resolved fluorescence assay for androgen and estrogen steroidogenesis screening', Garnovskaya, et... -
Federal
Defining the Taxonomic Domain of Applicability for Mammalian-Based High-Throughput Screening Assays
U.S. Environmental Protection Agency —
Final Data SeqAPASS v3.0.zip contains datasets from Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool versions 3.0 for all 497 proteins...