28 datasets found
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Federal
Technical evaluation and standardization of the human thyroid microtissue assay
U.S. Environmental Protection Agency —
Dataset for Foley et al. 'Technical evaluation and standardization of the human thyroid microtissue assay'; Toxicological Sciences, Vol 199, Issue 1, pg 89-107,... -
Federal
Dataset and code for cross species applicability of an AOP network for thyroid hormone system disruption
U.S. Environmental Protection Agency —
The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database... -
Federal
Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of metamorphic success in model amphibian Xenopus laevis
U.S. Environmental Protection Agency —
These data are represented in tables and graphs in the article, "Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine... -
Federal
Fetal and Postnatal Cortical Thyroid Hormone Levels and Bioindicators
U.S. Environmental Protection Agency —
thyroid hormones in serum and in brain were measured in fetal and neonatal rat cortex after graded levels of a thyroid hormone synthesis inhibitor were administered... -
Federal
Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents
U.S. Environmental Protection Agency —
Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the... -
Federal
Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models
U.S. Environmental Protection Agency —
How to access data for "Decrane R, Stoker T, Murr A, Ford J, El-Masri H. Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen... -
Federal
Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase
U.S. Environmental Protection Agency —
Supplementary materials for "Olker JH, Korte JJ, Haselman JT, Hornung MW, Degitz SJ. Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine... -
Federal
Data Table for Figures
U.S. Environmental Protection Agency —
This excel file contains 7 tabs, each tabs contains the data for one specific figure in the paper. Description of the data and column names is also provided in each... -
Federal
Impaired swim bladder inflation in early-life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid
U.S. Environmental Protection Agency —
The present study investigated whether inhibition of deiodinase, the enzyme which converts thyroxine (T4) to the more biologically-active form,... -
Federal
Characterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines
U.S. Environmental Protection Agency —
Biomarker Image Cytometry. The cell-level frequency of NK2 Homeobox 1 (NKX2-1), Keratin 7 (KRT7), and Thyroglobulin (TG) protein staining were quantitatively... -
Federal
Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Male Rats
U.S. Environmental Protection Agency —
behavioral measures of learning and memory in adult offspring of rats treated with thyroid hormone synthesis inhibitor, propylthiouracil. Electrophysiological... -
Federal
Gestational Exposure to Perchlorate in the rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain
U.S. Environmental Protection Agency —
This dataset contains results from rodent study. Thyroid hormones and brain endpoints are reported for pregnant rat dams and progeny on gestational day 20 following... -
Federal
Data supporting amphibian thyroid model parameterization
U.S. Environmental Protection Agency —
This dataset was generated to support parameterization of a larval amphibian thyroid axis computational model. Specifically, plasma iodine levels were determined not... -
Federal
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
U.S. Environmental Protection Agency —
Supplementary data for "Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung, Sigmund J. Degitz, Assessing utility of thyroid in vitro... -
Federal
Raw data presented in manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the Postnatal Rat Brain" by O'Shaughnessy et al. 2024.
U.S. Environmental Protection Agency —
Raw data to accompanying manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the... -
Federal
FRTL-5 RAIU of 5-AT
U.S. Environmental Protection Agency —
Iodide uptake following a two-hour incubation with concentrations of 5-ATcompared to control iodide uptake in FRTL thyroid follicular cells. This dataset is... -
Federal
Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening
U.S. Environmental Protection Agency —
The objective of this study was to develop a medium-throughput organotypic screening assay comprised of reconstructed human thyroid microtissues to quantitatively... -
Federal
Effects of deiodinase inhibition on amphibian metamorphosis
U.S. Environmental Protection Agency —
This dataset contains in vitro and in vivo biochemical and apical (i.e., growth/development) data pertaining to iodotyrosine deiodinase inhibition in the African... -
Federal
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter
U.S. Environmental Protection Agency —
Abbreviations and data for manuscript Figures in the main text and supplemental. This dataset is associated with the following publication: Stoker, T., J. Want, A.... -
Federal
Iodotyrosine deiodinase: mRNA expression and experimental inhibition study in Xenopus laevis
U.S. Environmental Protection Agency —
This excel file contains the resultant data from a study on iodotyrosine deiodinase in the model amphibian species, Xenopus laevis. These data include: tadpole growth...
28 datasets found