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Federal
Protein Data Bank (PDB)
U.S. Department of Health & Human Services —
The Protein Data Bank (PDB) archive is the single worldwide repository of information about the 3D structures of large biological molecules, including proteins and... -
Federal
Blood substitutes Artificial oxygen carriers: perfluorocarbon emulsions
U.S. Department of Health & Human Services —
Perfluorocarbon emulsions are being clinically evaluated as artificial oxygen carriers to reduce allogeneic blood transfusions or to improve tissue oxygenation.... -
Federal
Genomic regions that underlie soybean seed isoflavone content
U.S. Department of Health & Human Services —
Soy products contain isoflavones (genistein, daidzein, and glycitein) that display biological effects when ingested by humans and animals, these effects are species,... -
Federal
Return to fertility after extended chemical castration with a GnRH antagonist
U.S. Department of Health & Human Services —
Background Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is... -
Federal
Taking stock of gene therapy for cystic fibrosis
U.S. Department of Health & Human Services —
The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal... -
Federal
Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens
U.S. Department of Health & Human Services —
Background In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit superior performance to females (a difference attributed to the hormonal... -
Federal
High copy arrays containing a sequence upstream of
U.S. Department of Health & Human Services —
Background The Caenorhabditis elegans gene mec-3 encodes a LIM-homeodomain protein that is a master regulator of touch receptor neuron genes. Two of the touch... -
Federal
Patent AT-E401784-T1: [Translated] SELECTION SYSTEM AND METHOD FOR MILKING ANIMALS
U.S. Department of Health & Human Services —
A selection system for animals comprising: (a) a milking area ( 20 ) arranged to enable milking of one or more lactating animals (b) a drinking station ( 30 ) remote... -
Federal
Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
U.S. Department of Health & Human Services —
Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial... -
Federal
Complete genome sequence of a novel extrachromosomal virus-like element identified in planarian
U.S. Department of Health & Human Services —
Background Freshwater planarians are widely used as models for investigation of pattern formation and studies on genetic variation in populations. Despite extensive... -
Federal
What have transgenic and knockout animals taught us about respiratory disease?
U.S. Department of Health & Human Services —
Over the past decade there has been a significant shift to the use of murine models for investigations into the molecular basis of respiratory diseases, including... -
Federal
Genetic epidemiology: Systemic sclerosis
U.S. Department of Health & Human Services —
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterised phenotypically by fibrosis and ischaemic atrophy. Its aetiology is most likely... -
Federal
Calcium dynamics during fertilization in
U.S. Department of Health & Human Services —
Background Of the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model... -
Federal
Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
U.S. Department of Health & Human Services —
Background Elevated intracranial pressure (ICP) resulting from impaired drainage of cerebrospinal fluid (CSF) causes hydrocephalus with damage to the central nervous... -
Federal
Hypothermia and neurologic outcome in patients following cardiac arrest: should we be hot to cool off our patients?
U.S. Department of Health & Human Services —
Hypothermia as a protectant of neurologic function in the treatment of cardiac arrest patients, although not a new concept, is now supported by two recent randomized,... -
Federal
A short purification process for quantitative isolation of PrP
U.S. Department of Health & Human Services —
Background Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases affecting both humans and animals. They are associated with post-... -
Federal
Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV-infected mice
U.S. Department of Health & Human Services —
Background Acyclovir (ACV) resistant herpes simplex virus (HSV) isolates can be readily selected in animal infection models receiving suboptimal ACV treatment,... -
Federal
Gastric stimulation: influence of electrical parameters on gastric emptying in control and diabetic rats
U.S. Department of Health & Human Services —
Background The aim of this study was to test the effect of different pulse frequencies and amplitudes during gastric stimulation (GS) on gastric emptying in the rat.... -
Federal
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
U.S. Department of Health & Human Services —
Background The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In... -
Federal
MCMV induces neointima in IFN-γR-/- mice: Intimal cell apoptosis and persistent proliferation of myofibroblasts
U.S. Department of Health & Human Services —
Background CMV infections have been linked to vasculopathies like atherosclerosis and Scleroderma. CMV infects vascular endothelium with intermittent shedding of the...