Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
Background:
Increased serum levels of procalcitonin (ProCT) and its component
peptides have been reported in humans with sepsis. Using a hamster model of
bacterial peritonitis, we investigated whether serum ProCT levels are elevated
and correlate with mortality and hypocalcemia.
Results:
Incremental increases in doses of bacteria resulted in
proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as
increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250,
380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml).
Gel filtration studies revealed that ProCT was the predominant (> 90%)
molecular form of serum iCT secreted. In the metabolic experiments, total iCT
peaked at 12 h concurrent with the maximal decrease in serum calcium.
Conclusions:
In this animal model, hyper-procalcitoninemia was an early
systemic marker of sepsis which correlated closely with mortality and had an
inverse correlation with serum calcium levels.
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "009:25" ] |
| contactPoint |
{ "fn": "NIH", "@type": "vcard:Contact", "hasEmail": "mailto:info@nih.gov" } |
| description | Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. Results: Incremental increases in doses of bacteria resulted in proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml). Gel filtration studies revealed that ProCT was the predominant (> 90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. Conclusions: In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels. |
| distribution |
[ { "@type": "dcat:Distribution", "title": "Official Government Data Source", "mediaType": "text/html", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29007/" } ] |
| identifier | https://healthdata.gov/api/views/v4da-zt5y |
| issued | 2025-07-13 |
| keyword |
[ "bacterial-peritonitis", "hamster-model", "nih", "procalcitonin-levels", "sepsis-mortality" ] |
| landingPage | https://healthdata.gov/d/v4da-zt5y |
| modified | 2025-09-06 |
| programCode |
[ "009:033" ] |
| publisher |
{ "name": "National Institutes of Health", "@type": "org:Organization" } |
| theme |
[ "NIH" ] |
| title | Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis |
