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Federal
Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins
U.S. Department of Health & Human Services —
Background NGF exerts a variety of actions including promotion of neuronal differentiation and survival. The PC12 rat pheochromocytoma cell line has proved valuable... -
Federal
Endothelial [Ca2+]iis an integrating signal for the vascular tone in rat aortae
U.S. Department of Health & Human Services —
Although various endothelium-dependent relaxing factors (endothelial autacoids) are released upon the elevation of endothelial cytosolic free Ca2+concentration (EC... -
Federal
Drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes
U.S. Department of Health & Human Services —
Background Thyroid hormones are well known modulators of signal transduction. The effect of hyper- and hypo-thyroidism on diacylglycerol/protein kinase C (DAG/PKC)... -
Federal
Debate: Unstable angina - When should we intervene?
U.S. Department of Health & Human Services —
The prognosis of patients who present with non-ST segment elevation acute coronary syndromes (ACS) is guarded. These patients can be risk-stratified on the basis of... -
Federal
Omapatrilat normalizes renal function curve in spontaneously hypertensive rats
U.S. Department of Health & Human Services —
Background The present study was designed to analyze the chronic renal response to omapatrilat, a new vasopeptidase inhibitor, in spontaneously hypertensive rats... -
Federal
Analysis of fluorescently labeled substance P analogs: binding, imaging and receptor activation
U.S. Department of Health & Human Services —
Background Substance P (SP) is a peptide neurotransmitter found in central and peripheral nerves. SP is involved in the control of smooth muscle, inflammation and... -
Federal
Patent AT-E399821-T1: [Translated] METHOD FOR THE POST-TREATMENT OF TITANIUM DIOXIDE PIGMENTS
U.S. Department of Health & Human Services —
The invention relates to a method for the post-treatment of titanium dioxide, in order to produce particularly weather-resistant titanium dioxide pigments with good... -
Federal
Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart
U.S. Department of Health & Human Services —
Background Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported... -
Federal
Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
U.S. Department of Health & Human Services —
Background Elevated intracranial pressure (ICP) resulting from impaired drainage of cerebrospinal fluid (CSF) causes hydrocephalus with damage to the central nervous... -
Federal
Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers
U.S. Department of Health & Human Services —
Background Mutations in the core promoter and precore regions of the hepatitis B virus (HBV) genome, notably the double substitution (AGG to TGA) at nt positions... -
Federal
Hepatic adverse events during highly active antiretroviral therapy containing nevirapine: a case report
U.S. Department of Health & Human Services —
Background Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV... -
Federal
Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice
U.S. Department of Health & Human Services —
Background The intrarenal natriuretic hormone dopamine (DA) is metabolised by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). Inhibition of COMT, as... -
Federal
Bone mineral density and the subsequent risk of cancer in the NHANES I follow-up cohort
U.S. Department of Health & Human Services —
Backgroud Bone mineral density (BMD) is a marker of long-term estrogen exposure. BMD measurement has been used in this context to investigate the association of... -
Federal
Debate: Should the elderly receive thrombolytic therapy or primary angioplasty?
U.S. Department of Health & Human Services —
Thrombolysis and primary angioplasty are both recommended reperfusion strategies for elderly patients presenting with myocardial infarction (MI). Primary angioplasty... -
Federal
Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis
U.S. Department of Health & Human Services —
BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine... -
Federal
Adhesion molecules in different treatments of acute myocardial infarction
U.S. Department of Health & Human Services —
Background: Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to... -
Federal
Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state
U.S. Department of Health & Human Services —
Background Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many... -
Federal
FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)
U.S. Department of Health & Human Services —
We investigated the role of Fcγ receptors (FcγRs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA elicited in knee joints of C57BL/6 mice... -
Federal
Polyomyositis and myocarditis associated with acquired toxoplasmosis in an immunocompetent girl
U.S. Department of Health & Human Services —
Background Acquired toxoplasmosis more frequently goes unrecognized. Immunocompetent adults and adolescents with primary infection are generally asymptomatic, but... -
Federal
Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
U.S. Department of Health & Human Services —
Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial...