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Prehospital point of care testing of blood gases and electrolytes — an evaluation of IRMA
Background: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. Results: A portable,... -
Severe community-acquired meningitis
Community-acquired meningitis is associated with high morbidity and mortality. The epidemiology of community-acquired meningitis has changed over the past 15 years with the use... -
Use of complementary/alternative therapies by women with advanced-stage breast cancer
Background This study sought to describe the pattern of complementary/alternative medicine (CAM) use among a group of patients with advanced breast cancer, to examine the main... -
Optimizing antibiotic therapy in the intensive care unit setting
Antibiotics are one of the most common therapies administered in the intensive care unit setting. In addition to treating infections, antibiotic use contributes to the emergence... -
Critical advances in septicemia and septic shock
Recent advances suggest that toll-like receptors, various cytokines, cicosanoids, free radicals and macrophage migration inhibitory factor (MIF) play an important role in the... -
Bridging case-control studies and randomized trials
Randomized trials and observational studies, such as case-control studies, are often seen as opposing approaches. However, in many instances results obtained by different... -
The Adaptive Evolution Database (TAED)
Background The Master Catalog is a collection of evolutionary families, including multiple sequence alignments, phylogenetic trees and reconstructed ancestral sequences, for all... -
Oral sildenafil (Viagra™) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital.
Introduction Sildenafil (Viagra®) is one of the drugs used in the first line therapy of male erectile dysfunction (MED). We have recorded outcomes, adverse events and... -
Association of Down's syndrome and water fluoride level: a systematic review of the evidence
Background A review of the safety and efficacy of drinking water fluoridation was commissioned by the UK Department of Health to investigate whether the evidence supported a... -
Representation of women's health in general medical versus women's health specialty journals: a content analysis
Background Women's health, traditionally defined, emphasises reproductive and maternal conditions without consideration of social contexts. Advocates urge a broader... -
Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports
Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. Methods Clinical trial... -
Genetics of osteoarticular disorders, Florence, Italy, 22–23 February 2002
Osteoporosis (OP) and osteoarthritis (OA), the two most common age-related chronic disorders of articular joints and skeleton, represent a major public health problem in most... -
The baboon (
Background As novel endovascular strategies are developed for treating neurological disease, there is an increasing need to evaluate these techniques in relevant preclinical... -
Approaches to enhancing the retroviral transduction of human synoviocytes
This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic... -
Model-based cluster analysis of microarray gene-expression data
Background Microarray technologies are emerging as a promising tool for genomic studies. The challenge now is how to analyze the resulting large amounts of data. Clustering... -
Are plant formins integral membrane proteins?
Background: The formin family of proteins has been implicated in signaling pathways of cellular morphogenesis in both animals and fungi; in the latter case, at least, they... -
Organisational development in general practice: lessons from practice and professional development plans (PPDPs)
Background Improving the quality and effectiveness of clinical practice is becoming a key task within all health services. Primary medical care, as organised in the UK is... -
The effect of massage on localized lumbar muscle fatigue
Background There is not enough evidence to support the efficacy of massage for muscle fatigue despite wide utilization of the modality in various clinical settings. This study... -
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased...
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