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Aggregated Computational Toxicology Online Resource
Aggregated Computational Toxicology Online Resource (AcTOR) is EPA's online aggregator of all the public sources of chemical toxicity data. ACToR aggregates data from over 1,000... -
Consumer Product Category Database
The Chemical and Product Categories database (CPCat) catalogs the use of over 40,000 chemicals and their presence in different consumer products. The chemical use information is... -
SSDn insecticide dataset
This is a dataset of acute toxicity values for organophosphate and carbamate insecticides. the dataset is used to develop and validate the species sensitivity distribution... -
ToxCast Phase I
Background: Chemical toxicity testing is being transformed by advances in biology and computer modeling, concerns over animal use and the thousands of environmental chemicals... -
Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling
In the present study, we adapted an existing phenotypic profiling assay (“Cell Painting”, (Bray et al., 2016)) to be compatible with in-house microfluidics capabilities for... -
The Residential Population Generator (RPGen): A tool to parameterize residential, demographic, and physiological data to model intraindividual exposure, dose, and risk
This repository contains scripts, input files, and some example output files for the Residential Population Generator, an R-based tool to generate synthetic human residental... -
Dataset for 'Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping'
Dataset for Harrill, J.A. et al., 'Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping' published in... -
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
The contents of the chemistry database, presently containing ~ 760,000 substances, are available as public domain data for download. The chemistry content underpinning the... -
Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity
This dataset consists of data from in vitro developmental neurotoxicity new approach methodologies (DNT-NAMs). Assays include evaluations of proliferation, apoptosis, viability,... -
High-Throughput Transcriptomics Screen of ToxCast Chemicals in U-2 OS Cells
Supplemental datafiles for journal article 'High-Throughput Transcriptomics Screen of ToxCast Chemicals in U-2 OS Cells'. -
Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space
Chemical toxicity can arise from disruption of specific biomolecular functions or through more generalized cell stress and cytotoxicity-mediated processes. Here, concentration-... -
Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the food-relevant... -
Distributed Structure Searchable Toxicity
The Distributed Structure Searchable Toxicity (DSSTox) online resource provides high quality chemical structures and annotations in association with toxicity data. It helps to... -
Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods
Dataset for "Nicolas Chantel I., Linakis Matthew W., Minto Melyssa S., Mansouri Kamel, Clewell Rebecca A., Yoon Miyoung, Wambaugh John F., Patlewicz Grace, McMullen Patrick D.,... -
High-Throughput Transcriptomics Platform for Screening Environmental Chemicals
We screened 44 chemicals in MCF7 cells in concentration response and generated HTTr data using the TempO-Seq hWTv1 assay. First, we provide an outline of the quality of the HTTr... -
Chemical agnostic hazard prediction: Statistical inference of toxicity pathways - data for Figure 2
This dataset comprises one SigmaPlot 13 file containing measured survival data and survival data predicted from the model coefficients selected by the LASSO procedure. This... -
Exposure Forecaster
The Exposure Forecaster Database (ExpoCastDB) is EPA's database for aggregating chemical exposure information and can be used to help with chemical exposure predictions. The... -
Phenotypic Profiling of Reference Chemicals across Biologically Diverse Cell Types Using the Cell Painting Assay
Cell Painting is a high-throughput, phenotypic profiling assay that uses fluorescent cytochemistry o visualize a variety of organelles and high-content imaging to derive a large... -
From Protein Sequence to Structure: The Next Frontier in Cross-Species Extrapolation for Chemical Safety Evaluations
Supplemental data for "LaLone CA, Blatz DJ, Jensen MA, Vliet SMF, Mayasich S, Mattingly KZ, Transue TR, Melendez W, Wilkinson A, Simmons CW, Ng C, Zhang C, Zhang Y. From Protein...
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