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    • Dataset for 'Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping'

    Metadata Updated: January 9, 2025

    Dataset for Harrill, J.A. et al., 'Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping' published in Toxicological Sciences, https://doi.org/10.1093/toxsci/kfae108

    This dataset contains gene expression profiles and gene signature concentration-response modeling results for 1751 unique chemicals. The chemicals were tested in MCF7 cells using an exposure duration of six hours. The datasets also contains the results of molecular target enrichment and chemotype enrichment analyses performed downstream of the gene signature concentration-response modeling.

    Descriptions of each data file can be found in the supplementary material of the published article that is hosted by the journal.

    This dataset is associated with the following publication: Harrill, J., L. Everett, D. Haggard, L. Word, J. Bundy, B. Chambers, D. Harris, C. Willis, R. Thomas, I. Shah, and R. Judson. Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 202(1): 103-122, (2024).

    Access & Use Information

    Public: This dataset is intended for public access and use. License: See this page for license information.

    Downloads & Resources

    References

    https://doi.org/10.1093/toxsci/kfae108

    Dates

    Metadata Created Date January 9, 2025
    Metadata Updated Date January 9, 2025

    Metadata Source

    Harvested from EPA ScienceHub

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date January 9, 2025
    Metadata Updated Date January 9, 2025
    Publisher U.S. EPA Office of Research and Development (ORD)
    Maintainer
    Identifier https://doi.org/10.23719/1531711
    Data Last Modified 2024-07-09
    Public Access Level public
    Bureau Code 020:00
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Harvest Object Id dae07693-cb8c-4aa6-9ef7-ff2f885b067b
    Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
    Harvest Source Title EPA ScienceHub
    License https://pasteur.epa.gov/license/sciencehub-license.html
    Program Code 020:000
    Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
    Related Documents https://doi.org/10.1093/toxsci/kfae108
    Source Datajson Identifier True
    Source Hash 95b09d7b89f5e5da99a1c5f28c42a092dc3e376b610dfd629140310a63fee95f
    Source Schema Version 1.1

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