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Response to Low Shear Modeled Microgravity Indicates Translation of Lactobacillus acidophilus ATCC 4356 Benefits to Spaceflight

Metadata Updated: December 6, 2023

The introduction of generally recognized as safe (GRAS) probiotic microbes into the spaceflight food system has the potential for use as a safe non-invasive daily countermeasure to crew microbiome and immune dysregulation. However the microgravity effects on the stress tolerances and genetic expression of probiotic bacteria must be determined to confirm translation of strain benefits and to identify potential for optimization of growth survival and strain selection for spaceflight. The work presented here demonstrates the translation of characteristics of a GRAS probiotic bacteria to a microgravity analog environment. Lactobacillus acidophilus ATCC 4356 was grown in the low shear modeled microgravity (LSMMG) orientation and the control orientation in the rotating wall vessel (RWV) to determine the effect of LSMMG on the growth survival through stress challenge and gene expression of the strain. No differences were observed between the LSMMG and control grown L. acidophilus suggesting that the strain will behave similarly in spaceflight and may be expected to confer Earth-based benefits.

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Public: This dataset is intended for public access and use. License: us-pd

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Metadata Created Date January 31, 2023
Metadata Updated Date December 6, 2023
Data Update Frequency irregular

Metadata Source

Harvested from NASA Data.json

Additional Metadata

Resource Type Dataset
Metadata Created Date January 31, 2023
Metadata Updated Date December 6, 2023
Publisher National Aeronautics and Space Administration
Identifier nasa_genelab_GLDS-199_i8th-whn4
Data First Published 2021-05-21
Data Last Modified 2023-01-26
Category Earth Science
Public Access Level public
Data Update Frequency irregular
Bureau Code 026:00
Metadata Context
Metadata Catalog ID
Schema Version
Catalog Describedby
Harvest Object Id 45849e86-e44b-4b9b-8400-0b6d222051e0
Harvest Source Id 58f92550-7a01-4f00-b1b2-8dc953bd598f
Harvest Source Title NASA Data.json
Homepage URL
Program Code 026:005
Source Datajson Identifier True
Source Hash 200310b404757be50978ae5124dad26528a0d369679f44dab0921f8e446f45fb
Source Schema Version 1.1

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