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    • Phenotypic Profiling of 6PPD, 6PPD-Quinone, and Structurally Diverse Antiozonants in RTgill-W1 Cells Using the Cell Painting Assay

    Metadata Updated: June 15, 2025

    Methods S1–S2 detailing laboratory and data analysis methods; tables describing materials used (Table S1), assay wells excluded from analyses (Table S2), sourcing information for test chemicals (Table S3), cell culture media (Table S4) and assay reagents (Table S5), and descriptions and metadata for data files S1–S9 (PDF) File S1 containing the 2D chemical structures for all antiozonant compounds tested in this study (PDF) File S2 containing the list of features used for profile correlation analysis (XLSX) File S3 containing graphs of each cell viability and Cell Painting concentration–response curve for all tested chemicals in the study (PDF) File S4 containing the curve-fitting results for the cell viability assay (XLSX) File S5 containing the curve-fitting results for the Cell Painting assay (XLSX) File S6 containing a list of all features collected during Cell Painting and their metadata (XLSX) File S7 containing the normalized well-level values for the Cell Painting assay (XLSX) File S8 containing global Mahalanobis distance values for the Cell Painting assay, 1 per well (XLSX) File S9 containing category Mahalanobis distance values for the Cell Painting assay, 49 per well (XLSX).

    This dataset is associated with the following publication: Harris, F., M. Jankowski, D. Villeneuve, and J. Harrill. Phenotypic Profiling of 6PPD, 6PPD-quinone and Structurally Diverse Antiozonants in RTgill-W1 Cells Using the Cell Painting Assay. Environmental Science & Technology Letters. American Chemical Society, Washington, DC, USA, 12(6): 695-701, (2025).

    Access & Use Information

    Public: This dataset is intended for public access and use. License: See this page for license information.

    Downloads & Resources

    References

    https://doi.org/10.1021/acs.estlett.5c00327

    Dates

    Metadata Created Date June 15, 2025
    Metadata Updated Date June 15, 2025

    Metadata Source

    Harvested from EPA ScienceHub

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date June 15, 2025
    Metadata Updated Date June 15, 2025
    Publisher U.S. EPA Office of Research and Development (ORD)
    Maintainer
    Identifier https://doi.org/10.23719/1532365
    Data Last Modified 2025-05-05
    Public Access Level public
    Bureau Code 020:00
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Harvest Object Id 6da0a007-65ba-4425-bf4c-70647f87f742
    Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
    Harvest Source Title EPA ScienceHub
    License https://pasteur.epa.gov/license/sciencehub-license.html
    Program Code 020:000
    Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
    Related Documents https://doi.org/10.1021/acs.estlett.5c00327
    Source Datajson Identifier True
    Source Hash 684ad284e91c89a04726c895e45c33c975ef8cdd1fd3c427924595983a2f2acb
    Source Schema Version 1.1

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