A spring wheat (Triticum aestivum L.) -corn (Zea mays L.) -soybean (Glycine max (L.) Merr.) rotation has become widespread in dry-land cropping systems in the northern Great Plains of the United States. But this region experiences extreme variability in climate, which is projected to increase in the future, and little is known about how seasonal weather changes impact this crop rotation in terms of carbon and water balances. To address this research gap, we analyzed micrometeorological and eddy covariance measurements through two rotations of spring wheat-corn-soybean in a no-till, rainfed field managed according to prevailing local practices near Mandan, ND USA. Using linear regression models, we found a negative correlation between vapor pressure deficit (VPD) and soil water content, which explained 84 % of the variation in net-ecosystem production (NEP) and 64 % of the variation in gross ecosystem production (GEP). Results also indicated that evapotranspiration (ET) across dormant and growing seasons among three crops (i.e., six crop-seasons) was mainly determined by VPD during the dormant season but a threshold ET was attained as VPD increased between growing seasons. Elevated temperatures during the dormant season explained 88 % of the variability in ecosystem respiration during the dormant season. These results imply that anticipated increases in evaporative demand due to elevated temperatures and/or low humidity in conjunction with soil drought may necessitate wider adoption of conservation agricultural practices that enhance soil moisture recharge during the dormant season.