14 datasets found
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Federal
Debate: A subversive view of subsets - a dissident clinician's opinion
U.S. Department of Health & Human Services —
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients... -
Federal
5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
U.S. Department of Health & Human Services —
Background Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly... -
Federal
Disagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study
U.S. Department of Health & Human Services —
Background Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal... -
Federal
Systematic adjudication of myocardial infarction end-points in an international clinical trial
U.S. Department of Health & Human Services —
Background Clinical events committees (CEC) are used routinely to adjudicate suspected end-points in cardiovascular trials, but little information has been published... -
Federal
Importance of the TIMI frame count: implications for future trials
U.S. Department of Health & Human Services —
Although the TIMI (Thrombolysis In Myocardial Infarction) flow grade classification scheme is widely used to assess angiographic outcomes, it is limited by poor... -
Federal
How long should angiotensin-converting enzyme inhibitors be given to patients following myocardial infarction: implications of the HOPE trial
U.S. Department of Health & Human Services —
Long-term treatment with angiotensin-converting enzyme inhibitors reduces post-infarction morbidity and mortality in patients with left ventricular (LV) systolic... -
Federal
T Wave Alternans in high arrhythmic risk patients: Analysis in time and frequency domains: A pilot study
U.S. Department of Health & Human Services —
Background T wave alternans (TA) is a repolarisation phenomenon manifesting as a microvolt beat to beat change in the amplitude of the T wave and ST segment. TA has... -
Federal
Adhesion molecules in different treatments of acute myocardial infarction
U.S. Department of Health & Human Services —
Background: Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to... -
Federal
Debate: Should the elderly receive thrombolytic therapy or primary angioplasty?
U.S. Department of Health & Human Services —
Thrombolysis and primary angioplasty are both recommended reperfusion strategies for elderly patients presenting with myocardial infarction (MI). Primary angioplasty... -
Federal
Is insulin an endogenous cardioprotector?
U.S. Department of Health & Human Services —
Stress hyperglycemia and diabetes mellitus with myocardial infarction are associated with increased risk for in-hospital mortality, congestive heart failure, or... -
Federal
Myocardial bridging as a cause of acute myocardial infarction: a case report
U.S. Department of Health & Human Services —
Background Systolic compression of a coronary artery by overlying myocardial tissue is termed myocardial bridging. Myocardial bridging usually has a benign prognosis,... -
Federal
Patients with suspected acute coronary syndrome in a university hospital emergency department: an observational study
U.S. Department of Health & Human Services —
Background It is widely considered that improved diagnostics in suspected acute coronary syndrome (ACS) are needed. To help clarify the current situation and the... -
Federal
Is there a clinically significant gender bias in post-myocardial infarction pharmacological management in the older (>60) population of a primary care practice?
U.S. Department of Health & Human Services —
Background Differences in the management of coronary artery disease between men and women have been reported in the literature. There are few studies of potential... -
Federal
Design of a randomized controlled trial of comprehensive rehabilitation in patients with myocardial infarction, stabilized acute coronary syndrome, percutaneous transluminal coronary angioplasty or coronary artery bypass grafting: Akershus Comprehensive C
U.S. Department of Health & Human Services —
Objectives 1. To assess the long-term effectiveness of a comprehensive cardiac rehabilitation programme on quality of life and survival in patients with a large...
14 datasets found