17 datasets found
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Federal
PBPK_modeloutputs_readme
U.S. Environmental Protection Agency —
Contains values from pbpk models for each study on n-butanol effects. This dataset is associated with the following publication: Segal, D., A. Bale, L. Phillips, A.... -
Federal
Moser_NTT_52:2015
U.S. Environmental Protection Agency —
data supporting manuscript figures. This dataset is associated with the following publication: Moser , V.C., P. Phillips , J. Hedge , and K. Mcdaniel.... -
Federal
A comparative study of biostatistical pipelines for benchmark concentration modeling of in vitro screening assays
U.S. Environmental Protection Agency —
Supplementary data for "A comparative study of biostatistical pipelines for benchmark concentration modeling of in vitro screening assays". This dataset is associated... -
Federal
Iodine Deficiency Exacerbates Thyroidal and Neurological Effects of Developmental Perchlorate Exposure in the Neonatal and Adult Rat
U.S. Environmental Protection Agency —
Thyroid hormones status, brain molecular and structural changes, and neurobehavioral impairments following maternal exposure to perchlorate in a rodent pregnancy... -
Federal
Methods for Thyroid Hormone Measurements in Neonatal Rat Brain
U.S. Environmental Protection Agency —
Serum and brain thyroid hormone measurements in rat brain. This dataset is associated with the following publication: Gilbert, M., J. Ford, C. Riutta, K.... -
Federal
Data for: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays
U.S. Environmental Protection Agency —
This dataset contains the raw data, Area under the curve measurements and EC50 values for effects of 146 compounds (136 unique plus 10 biological replicates) on... -
Federal
Neurite outgrowth in human iPSC-derived neurons
U.S. Environmental Protection Agency —
Data on morphology of rat and human neurons in cell culture. This dataset is associated with the following publication: Druwe, I., T. Freudenrich , K. Wallace , T.... -
Federal
Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents
U.S. Environmental Protection Agency —
Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the... -
Federal
Gestational Exposure to Perchlorate in the rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain
U.S. Environmental Protection Agency —
This dataset contains results from rodent study. Thyroid hormones and brain endpoints are reported for pregnant rat dams and progeny on gestational day 20 following... -
Federal
Raw Data for Jarema et al, 2022 Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish...
U.S. Environmental Protection Agency —
The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxics10050256/s1. Figure S1, Effect of DMSO on Light/Dark Locomotor... -
Federal
This file contains data used to generate figures shown in Phelps et al. Microbial colonization is required for normal neurobehavioral development in zebrafish. Scientific Reports. 2017.
U.S. Environmental Protection Agency —
Data used to generate figures shown in Phelps et al. This dataset is associated with the following publication: Phelps, D., N. Brinkman, S. Keely, E. Anneken, T.... -
Federal
MEA 86 Compound data
U.S. Environmental Protection Agency —
This data file contains the full raw parameter data for the 86 compounds tested in the developmental MEA assay, as well as Area Under the Curve (AUC) calculations and... -
Federal
Doc Title: Adult Hippocampal Neurogenesis is Impaired by Transient Developmental Thyroid Hormone Disruption
U.S. Environmental Protection Agency —
Severe thyroid hormone (TH) deprivation during development impairs neurogenesis throughout the brain. The hippocampus also maintains a capacity for neurogenesis... -
Federal
Data for Brown et al MEA Developmental Neurotoxicity Screening Manuscript
U.S. Environmental Protection Agency —
These data are the individual parameter and well-level data that were support the conclusions in Brown et al. Note: the parameters CVtime and CVnetwork were not used.... -
Federal
Ammonium Perchlorate - Serum dosimetry, neurotoxicity and resilience of the neonatal rat thyroid system
U.S. Environmental Protection Agency —
Perchlorate is an environmental contaminant that interferes with iodine uptake via the NIS transporter into the thyroid gland, reducing thyroid hormone (TH)... -
Federal
Data for "Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain"
U.S. Environmental Protection Agency —
Raw data accompanying "Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain". This dataset is... -
Federal
Raw data presented in manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the Postnatal Rat Brain" by O'Shaughnessy et al. 2024.
U.S. Environmental Protection Agency —
Raw data to accompanying manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the...
17 datasets found